Apicomplexans are a group of pathogenic protists that cause various diseases in humans
and animals that cause economic losses worldwide. These unicellular eukaryotes are …

Malaria remains a serious threat to global health. Sustained malaria control and, eventually,
eradication will only be achieved with a broadly effective malaria vaccine. Yet a fundamental …

Malaria causes significant morbidity worldwide and a vaccine is urgently required.
Plasmodium infection causes considerable immune dysregulation, and elicitation of vaccine …

Clearing blood-stage malaria parasites without inducing major host pathology requires a
finely tuned balance between pro-and anti-inflammatory responses. The interplay between …

Abstract Background. Dendritic cells (DCs) are highly specialized antigen-presenting cells
that are crucial for initiation of immune responses. During naturally acquired malaria, DC …

Chronic Schistosoma infection is often characterized by a state of T cell hyporesponsiveness
of the host. Suppression of dendritic cell (DC) function could be one of the mechanisms …

Background Malaria in pregnancy is associated with immunological abnormalities in the
newborns, such as hampered T-helper 1 responses and increased T-regulatory responses …

In most tropical areas, pregnant women are at increased risk of malaria, as a consequence
of the massive sequestration of parasitized red blood cells in the placenta. The placenta …

Sequestration of Plasmodium falciparum-infected erythrocytes in placental intervillous
spaces causes inflammation and pathology. Knowledge of the profiles of immune cells …

Immunity to malaria can be acquired but only after repeat exposures to polymorphic
Plasmodium. However, the development of clinical outcomes during P. falciparum infection …