Aging is an intricate phenomenon characterized by progressive decline in physiological
functions and increase in mortality that is often accompanied by many pathological …

Abstract Beckman, Kenneth B., and Bruce N. Ames. The Free Radical Theory of Aging
Matures. Physiol. Rev. 78: 547–581, 1998.—The free radical theory of aging, conceived in …

Mutations in mitochondrial DNA (mtDNA) accumulate in tissues of mammalian species and
have been hypothesized to contribute to aging. We show that mice expressing a …

In humans, aging is inexorable. The progressive decrease in physiological capacity and the
reduced ability to respond to environmental stresses lead to increased susceptibility and …

Background Aging results in a progressive loss of skeletal muscle, a condition known as
sarcopenia. Mitochondrial DNA (mtDNA) mutations accumulate with aging in skeletal …

Aging is associated with a progressive loss of skeletal muscle mass and strength and the
mechanisms mediating these effects likely involve mitochondrial DNA (mtDNA) mutations …

Sarcopenia is a well-known geriatric syndrome that has been endorsed over the years as a
biomarker allowing for the discrimination, at a clinical level, of biological from chronological …

Mitochondria are characterized by its pivotal roles in managing energy production, reactive
oxygen species, and calcium, whose aging‐related structural and functional deteriorations …

This review is devoted to the molecular genetics and bioenergetics of human mitochondria
related to the mechanism of aging. Morphological and functional changes of mitochondria …

The purpose of the present study was to examine the role of mitochondria in the aging
process by determining whether the activities of various electron transport chain …