Prostate cancer is the most frequent nonskin cancer and second most common cause of
cancer-related deaths in man. Prostate cancer is a clinically heterogeneous disease with …

Research in the last decade has clearly revealed a critical role of prostate cancer stem cells
(PCSCs) in prostate cancer (PC). Prostate stem cells (PSCs) reside in both basal and …

Activation of the EGF receptors EGFR (ErbB1) and HER2 (ErbB2) drives the progression of
multiple cancer types through complex mechanisms that are still not fully understood. In this …

The cells of the prostate gland are dependent on cell signaling pathways to regulate their
growth, maintenance and function. However, perturbations in key signaling pathways …

Self-renewing colorectal cancer stem/progenitor cells (CSC) contribute to tumor
maintenance and resistance to therapy. Therapeutic targeting of CSCs could improve …

Androgen deprivation therapy or ADT is one of the cornerstones of management of locally
advanced or metastatic prostate cancer, alongside radiation therapy. However, despite early …

Head and neck squamous cell carcinomas (HNSCCs) harbor a subset of cells that are CD44
(+) and present with malignancy and radiotherapy resistance. As a key regulator of self …

Background The identification of signaling pathways that affect the cancer stem-like
phenotype may provide insights into therapeutic targets for combating embryonal …

Neuroendocrine differentiation (NED) secondary to androgen deprivation therapy (ADT)
may be frequent in various stages of prostate cancer (PC), particularly in castration-resistant …

SOX2 is an essential transcription factor for stem cells and plays a role in tumorigenesis,
however its role in prostate cancer stem cells (PCSCs) remains unclear. We report here a …