Employment of enhanced permeability and retention effect (EPR): Nanoparticle-based precision tools for targeting of therapeutic and diagnostic agent in cancer
In tumorous tissues, the absence of vasculature supportive tissues intimates the formation of
leaky vessels and pores (100 nm to 2 μm in diameter) and the poor lymphatic system offers …
leaky vessels and pores (100 nm to 2 μm in diameter) and the poor lymphatic system offers …
Nanomedicine-based delivery strategies for breast cancer treatment and management
Breast cancer is one of the most common types of cancer among women globally. It is
caused by mutations in the estrogen/progesterone receptors and conventional treatment …
caused by mutations in the estrogen/progesterone receptors and conventional treatment …
Overcoming the limits of hypoxia in photodynamic therapy: a carbonic anhydrase IX-targeted approach
A major challenge in photodynamic cancer therapy (PDT) is avoiding PDT-induced hypoxia,
which can lead to cancer recurrence and progression through activation of various …
which can lead to cancer recurrence and progression through activation of various …
Canine mammary tumors as a model for human disease
SM Abdelmegeed, S Mohammed - Oncology letters, 2018 - spandidos-publications.com
Animal models for examining human breast cancer (HBC) carcinogenesis have been
extensively studied and proposed. With the recent advent of immunotherapy, significant …
extensively studied and proposed. With the recent advent of immunotherapy, significant …
Targeting endothelial permeability in the EPR effect
The characteristics of the primary tumor blood vessels and the tumor microenvironment drive
the enhanced permeability and retention (EPR) effect, which confers an advantage towards …
the enhanced permeability and retention (EPR) effect, which confers an advantage towards …
Tumor microenvironment heterogeneity: challenges and opportunities
F Runa, S Hamalian, K Meade, P Shisgal… - Current molecular …, 2017 - Springer
The tumor microenvironment (TME) has been recognized as an integral component of
malignancies in breast and prostate tissues, contributing in confounding ways to tumor …
malignancies in breast and prostate tissues, contributing in confounding ways to tumor …
Challenges and opportunities in metastatic breast cancer treatments: Nano-drug combinations delivered preferentially to metastatic cells may enhance therapeutic …
Despite advances in breast cancer treatments and related 5-year survival outcomes,
metastatic breast cancer cures remain elusive. The current standard of care includes a …
metastatic breast cancer cures remain elusive. The current standard of care includes a …
[HTML][HTML] Current approaches for avoiding the limitations of circulating tumor cells detection methods—implications for diagnosis and treatment of patients with solid …
A Kowalik, M Kowalewska, S Góźdź - Translational Research, 2017 - Elsevier
Eight million people die of cancer each year and 90% of deaths are caused by systemic
disease. Circulating tumor cells (CTCs) contribute to the formation of metastases and thus …
disease. Circulating tumor cells (CTCs) contribute to the formation of metastases and thus …
[HTML][HTML] Artificial intelligence–aided diagnosis of breast cancer lymph node metastasis on histologic slides in a digital workflow
B Challa, M Tahir, Y Hu, D Kellough, G Lujan, S Sun… - Modern Pathology, 2023 - Elsevier
Identifying lymph node (LN) metastasis in invasive breast carcinoma can be tedious and
time-consuming. We investigated an artificial intelligence (AI) algorithm to detect LN …
time-consuming. We investigated an artificial intelligence (AI) algorithm to detect LN …
Brain metastasization of breast cancer
T Custodio-Santos, M Videira, MA Brito - Biochimica et Biophysica Acta …, 2017 - Elsevier
Central nervous system metastases have been reported in 15–25% of breast cancer
patients, and the incidence is increasing. Moreover, the survival of these patients is …
patients, and the incidence is increasing. Moreover, the survival of these patients is …