Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs

G Cirino, C Szabo… - Physiological …, 2023 - journals.physiology.org
Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …

Active sites and mechanism of oxygen reduction reaction electrocatalysis on nitrogen‐doped carbon materials

SK Singh, K Takeyasu, J Nakamura - Advanced Materials, 2019 - Wiley Online Library
The oxygen reduction reaction (ORR) is a core reaction for electrochemical energy
technologies such as fuel cells and metal–air batteries. ORR catalysts have been limited to …

Chemical Biology of H2S Signaling through Persulfidation

MR Filipovic, J Zivanovic, B Alvarez… - Chemical …, 2018 - ACS Publications
Signaling by H2S is proposed to occur via persulfidation, a posttranslational modification of
cysteine residues (RSH) to persulfides (RSSH). Persulfidation provides a framework for …

International union of basic and clinical pharmacology. CII: pharmacological modulation of H2S levels: H2S donors and H2S biosynthesis inhibitors

C Szabo, A Papapetropoulos - Pharmacological reviews, 2017 - ASPET
Over the last decade, hydrogen sulfide (H2S) has emerged as an important endogenous
gasotransmitter in mammalian cells and tissues. Similar to the previously characterized …

Biogenesis of reactive sulfur species for signaling by hydrogen sulfide oxidation pathways

TV Mishanina, M Libiad, R Banerjee - Nature chemical biology, 2015 - nature.com
The chemical species involved in H2S signaling remain elusive despite the profound and
pleiotropic physiological effects elicited by this molecule. The dominant candidate …

[HTML][HTML] Hydrogen sulfide signaling in mitochondria and disease

B Murphy, R Bhattacharya, P Mukherjee - The FASEB Journal, 2019 - ncbi.nlm.nih.gov
Hydrogen sulfide can signal through 3 distinct mechanisms: 1) reduction and/or direct
binding of metalloprotein heme centers, 2) serving as a potent antioxidant through reactive …

Links between metabolism and cancer

CV Dang - Genes & development, 2012 - genesdev.cshlp.org
Metabolism generates oxygen radicals, which contribute to oncogenic mutations. Activated
oncogenes and loss of tumor suppressors in turn alter metabolism and induce aerobic …

Redox chemistry and chemical biology of H2S, hydropersulfides, and derived species: implications of their possible biological activity and utility

K Ono, T Akaike, T Sawa, Y Kumagai, DA Wink… - Free Radical Biology …, 2014 - Elsevier
Hydrogen sulfide (H 2 S) is an endogenously generated and putative signaling/effector
molecule. Despite its numerous reported functions, the chemistry by which it elicits its …

[HTML][HTML] Hydrogen sulfide chemical biology: pathophysiological roles and detection

GK Kolluru, X Shen, SC Bir, CG Kevil - Nitric oxide, 2013 - Elsevier
Hydrogen sulfide (H 2 S) is the most recent endogenous gasotransmitter that has been
reported to serve many physiological and pathological functions in different tissues. Studies …

Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part I. Biochemical and physiological mechanisms

C Szabo, C Ransy, K Módis… - British journal of …, 2014 - Wiley Online Library
Until recently, hydrogen sulfide (H2S) was exclusively viewed a toxic gas and an
environmental hazard, with its toxicity primarily attributed to the inhibition of mitochondrial C …