Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease with a strong
inflammatory component. The latest studies indicate that innate immunity and inflammatory …

Underlying type 1 diabetes is a genetic aetiology dominated by the influence of specific HLA
haplotypes involving primarily the class II DR-DQ region. In genetically predisposed children …

Type 1 diabetes (T1D) results from a T cell–mediated destruction of pancreatic β-cells
following the infiltration of leukocytes (including CD8+, CD4+, and CD20+ cells) into and …

The preclinical phase of autoimmune disorders is characterized by an initial asymptomatic
phase of varying length followed by nonspecific signs and symptoms. A variety of …

Stem cells are fundamental units for achieving regenerative therapies, which leads naturally
to a theoretical and experimental focus on these cells for therapeutic screening and …

We review the current knowledge of pancreas pathology in type 1 diabetes. During the last
two decades, dedicated efforts toward the recovery of pancreas from deceased patients with …

Resident microbes play important roles in the development of the gastrointestinal tract, but
their influence on other digestive organs is less well explored. Using the gnotobiotic …

Aims/hypothesis A reliable method for in vivo quantification of pancreatic beta cell mass
(BCM) could lead to further insight into the pathophysiology of diabetes. The glucagon-like …

ApoA-I—the main apolipoprotein constituent of the HDL (high-density lipoprotein) fraction of
human plasma—is of therapeutic interest because it has several cardioprotective functions …

Type 1 diabetes (T1D) is a chronic autoimmune disease in which autoreactive T‐cells and
inflammation cause severe loss of pancreatic beta cells. Insulitis, the pathologic hallmark of …