Emerging roles of innate and adaptive immunity in Alzheimer's disease
X Chen, DM Holtzman - Immunity, 2022 - cell.com
Alzheimer's disease (AD) is the most common neurodegenerative disease, with
characteristic extracellular amyloid-β (Aβ) deposition and intracellular accumulation of …
characteristic extracellular amyloid-β (Aβ) deposition and intracellular accumulation of …
T cells in health and disease
L Sun, Y Su, A Jiao, X Wang, B Zhang - Signal transduction and …, 2023 - nature.com
T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …
mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern
INTRODUCTION Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA
vaccines are highly effective at preventing infection and especially severe disease …
vaccines are highly effective at preventing infection and especially severe disease …
Cellular and humoral immune responses following SARS-CoV-2 mRNA vaccination in patients with multiple sclerosis on anti-CD20 therapy
SARS-CoV-2 messenger RNA vaccination in healthy individuals generates immune
protection against COVID-19. However, little is known about SARS-CoV-2 mRNA vaccine …
protection against COVID-19. However, little is known about SARS-CoV-2 mRNA vaccine …
Distinct antibody and memory B cell responses in SARS-CoV-2 naïve and recovered individuals after mRNA vaccination
mRNA vaccines for SARS-CoV-2 have been authorized for emergency use. Despite their
efficacy in clinical trials, data on mRNA vaccine–induced immune responses are mostly …
efficacy in clinical trials, data on mRNA vaccine–induced immune responses are mostly …
Designing spatial and temporal control of vaccine responses
Vaccines are the key technology to combat existing and emerging infectious diseases.
However, increasing the potency, quality and durability of the vaccine response remains a …
However, increasing the potency, quality and durability of the vaccine response remains a …
Immunogenicity and toxicity of AAV gene therapy
HCJ Ertl - Frontiers in Immunology, 2022 - frontiersin.org
Gene transfer using adeno-associated viral (AAV) vectors has made tremendous progress in
the last decade and has achieved cures of debilitating diseases such as hemophilia A and …
the last decade and has achieved cures of debilitating diseases such as hemophilia A and …
Antibody-mediated neutralization of SARS-CoV-2
Neutralizing antibodies can block infection, clear pathogens, and are essential to provide
long-term immunity. Since the onset of the pandemic, SARS-CoV-2 neutralizing antibodies …
long-term immunity. Since the onset of the pandemic, SARS-CoV-2 neutralizing antibodies …
[HTML][HTML] Antibodies from primary humoral responses modulate the recruitment of naive B cells during secondary responses
Vaccines generate high-affinity antibodies by recruiting antigen-specific B cells to germinal
centers (GCs), but the mechanisms governing the recruitment to GCs on secondary …
centers (GCs), but the mechanisms governing the recruitment to GCs on secondary …
[HTML][HTML] Nanoparticle vaccines based on the receptor binding domain (RBD) and heptad repeat (HR) of SARS-CoV-2 elicit robust protective immune responses
Various vaccine strategies have been proposed in response to the global COVID-19
pandemic, each with unique strategies for eliciting immune responses. Here, we developed …
pandemic, each with unique strategies for eliciting immune responses. Here, we developed …