Vascular injury, characterized by endothelial dysfunction, structural remodelling,
inflammation and fibrosis, plays an important role in cardiovascular diseases. Cellular …

Gut microbiota in hypertension : Current Opinion in Nephrology and Hypertension Gut
microbiota in hypertension : Current Opinion in Nephrology and Hypertension Log in or …

Rare autosomal dominant tubulointerstitial kidney disease is caused by mutations in the
genes encoding uromodulin (UMOD), hepatocyte nuclear factor-1β (HNF1B), renin (REN) …

ATPase H+-transporting lysosomal accessory protein 2 (Atp6ap2), also known as the (pro)
renin receptor, is a type 1 transmembrane protein and an accessory subunit of the vacuolar …

Since the kidney is integral to maintenance of fluid and ion homeostasis, and therefore
blood pressure regulation, its proper function is paramount. Circadian fluctuations in blood …

Salt sensitive hypertension is characterized by increases in blood pressure in response to
increases in dietary salt intake and is associated with an enhanced risk of cardiovascular …

The renin-angiotensin-aldosterone system (RAAS) is a central element in the control of the
salt and water balance of the body and arterial blood pressure. The activity of the RAAS is …

Recent studies have provided further evidence for the presence of many components of the
RAS in glomerular structures, which supports the importance of locally produced …

The inability of mineralocorticoid receptor (MR) blockade to reduce hypertension associated
with high angiotensin (Ang) II suggests direct actions of Ang II to regulate tubular sodium …

Activation of (pro) renin receptor (PRR) is involved in the progression of chronic kidney
disease. However, the role of indoxyl sulfate, a uremic toxin, in the activation of PRR is not …