Proteins generally will tend to aggregate under a variety of environmental conditions in
comparison with small drug molecules. The extent of aggregation is dependent on many …

The pharmaceutical and biotech industries face continued pressure to reduce development
costs and accelerate process development. This challenge occurs alongside the need for …

Starch is a polymer of glucose linked to one another through the C1 oxygen, known as the
glycosidic bond. Amylases are capable of digesting these glycosidic linkages found in …

BACKGROUND: Biosimilars are defined as biologic products that are highly similar to
reference products, notwithstanding minor differences in clinically inactive components, with …

Komagataella phaffii, also known as Pichia pastoris, is a common host for the production of
biologics and enzymes, due to fast growth, high productivity, and advancements in host …

Abstract pelB has been known as a successful signal peptide to translocate the protein
target extracellularly in the Escherichia coli system. However, in our previous study, the yield …

Purpose To investigate antibody stability and formation of modified species under upstream
processing conditions. Methods The stability of 11 purified monoclonal human IgG1 and …

The demand for food-grade β-mannanases, ideal for high-temperature baking, is increasing.
Using the Komagataella phaffii (P. pastoris) expression system for β-mannanase production …

A simple high yielding process for the production of rhGH (recombinant human growth
hormone) in the Pichia pastoris system is described. The approach adopted the addition of …

Active ingredients of biopharmaceuticals consist of a wide array of biomolecular structures,
including those of enzymes, monoclonal antibodies, nucleic acids, and recombinant …