Trends in droplet microfluidics: From droplet generation to biomedical applications

Z Chen, S Kheiri, EWK Young, E Kumacheva - Langmuir, 2022 - ACS Publications
Over the past decade, droplet microfluidics has attracted growing interest in biology,
medicine, and engineering. In this feature article, we review the advances in droplet …

A high‐throughput biomimetic bone‐on‐a‐chip platform with artificial intelligence‐assisted image analysis for osteoporosis drug testing

K Paek, S Kim, S Tak, MK Kim, J Park… - Bioengineering & …, 2023 - Wiley Online Library
Although numerous organ‐on‐a‐chips have been developed, bone‐on‐a‐chip platforms
have rarely been reported because of the high complexity of the bone microenvironment …

Sorting Technology for Mesenchymal Stem Cells from a Single Tissue Source

X Feng, F Qi, H Wang, W Li, Y Gan, C Qi, Z Lin… - Stem Cell Reviews and …, 2024 - Springer
Mesenchymal stem cells (MSCs) are adult stem cells that can be obtained, enriched and
proliferated in vitro. They owned enormous potential in fields like regenerative medicine …

Fabrication of stiffness gradients of GelMA hydrogels using a 3D printed micromixer

A Lavrentieva, T Fleischhammer… - Macromolecular …, 2020 - Wiley Online Library
Many properties in both healthy and pathological tissues are highly influenced by the
mechanical properties of the extracellular matrix. Stiffness gradient hydrogels are frequently …

Heterogeneous expression of alternatively spliced lncRNA mediates vascular smooth cell plasticity

JM Mayner, EM Masutani… - Proceedings of the …, 2023 - National Acad Sciences
9p21. 3 locus polymorphisms have the strongest correlation with coronary artery disease,
but as a noncoding locus, disease connection is enigmatic. The lncRNA ANRIL found in …

Targeted therapeutics delivery by exploiting biophysical properties of senescent cells

J Low, B Chan, A Tay - Advanced Functional Materials, 2022 - Wiley Online Library
Cellular senescence refers to a state of irreversible arrest of cell proliferation in response to
various forms of cellular stress. It is known that the accumulation of senescent cells is a …

Chemotaxis and topotaxis add vectorially for amoeboid cell migration

JAJ Wondergem, M Mytiliniou, FCH Wit, TGA Reuvers… - bioRxiv, 2019 - biorxiv.org
Cells encounter a wide variety of physical and chemical cues when navigating their native
environments. However, their response to multiple simultaneous cues is not yet clear. In …

[HTML][HTML] Emerging microfluidics-enabled platforms for osteoarthritis management: from benchtop to bedside

Z Zou, X Luo, Z Chen, YS Zhang, C Wen - Theranostics, 2022 - ncbi.nlm.nih.gov
Osteoarthritis (OA) is a prevalent debilitating age-related joint degenerative disease. It is a
leading cause of pain and functional disability in older adults. Unfortunately, there is no cure …

Optical trapping with holographically structured light for single-cell studies

M Lee, H Hugonnet, MJ Lee, Y Cho, YK Park - Biophysics Reviews, 2023 - pubs.aip.org
A groundbreaking work in 1970 by Arthur Ashkin paved the way for developing various
optical trapping techniques. Optical tweezers have become an established method for the …

High-throughput and label-free isolation of senescent murine mesenchymal stem cells

Z Chen, K Jiang, Z Zou, X Luo, CT Lim, C Wen - Biomicrofluidics, 2020 - pubs.aip.org
Under internal or external insults such as aging and oxidative stresses, cells are induced
into a senescent state and stop cellular division permanently. As senescent cells (SnCs) …