[HTML][HTML] Deciphering the role of structural variation in human evolution: a functional perspective
Advances in sequencing technologies have enabled the comparison of high-quality
genomes of diverse primate species, revealing vast amounts of divergence due to structural …
genomes of diverse primate species, revealing vast amounts of divergence due to structural …
TDP-43 chronic deficiency leads to dysregulation of transposable elements and gene expression by affecting R-loop and 5hmC crosstalk
Summary TDP-43 is an RNA/DNA-binding protein that forms aggregates in various brain
disorders. TDP-43 engages in many aspects of RNA metabolism, but its molecular roles in …
disorders. TDP-43 engages in many aspects of RNA metabolism, but its molecular roles in …
Genome graphs detect human polymorphisms in active epigenomic state during influenza infection
Genetic variants, including mobile element insertions (MEIs), are known to impact the
epigenome. We hypothesized that genome graphs, which encapsulate genetic diversity …
epigenome. We hypothesized that genome graphs, which encapsulate genetic diversity …
Correlation of myeloid-derived suppressor cell expansion with upregulated transposable elements in severe COVID-19 unveiled in single-cell RNA sequencing …
M Farahmandnejad, P Mosaddeghi, M Dorvash… - Biomedicines, 2024 - mdpi.com
Some studies have investigated the potential role of transposable elements (TEs) in COVID-
19 pathogenesis and complications. However, to the best of our knowledge, there is no …
19 pathogenesis and complications. However, to the best of our knowledge, there is no …
MATES: A Deep Learning-Based Model for Locus-specific Quantification of Transposable Elements in Single Cell
Transposable elements (TEs) are crucial for genetic diversity and gene regulation. Current
single-cell quantification methods often align multi-mapping reads to eitherbest …
single-cell quantification methods often align multi-mapping reads to eitherbest …
[HTML][HTML] Transposable elements may enhance antiviral resistance in HIV-1 elite controllers
Abstract Less than 0.5% of people living with HIV-1 are elite controllers (ECs)-individuals
who have a replication-competent viral reservoir in their CD4+ T cells but maintain …
who have a replication-competent viral reservoir in their CD4+ T cells but maintain …
Multi-species analysis of inflammatory response elements reveals ancient and lineage-specific contributions of transposable elements to NF-κB binding
L Wang, A Alizada, K Rathnakumar, N Khyzha, T Taylor… - bioRxiv, 2022 - biorxiv.org
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is an essential and
evolutionarily conserved transcription factor complex primarily involved in innate immunity …
evolutionarily conserved transcription factor complex primarily involved in innate immunity …
Cryptic endogenous retrovirus subfamilies in the primate lineage
Many endogenous retroviruses (ERVs) in the human genome are primate-specific and have
contributed novel cis-regulatory elements and transcripts. However, current approaches for …
contributed novel cis-regulatory elements and transcripts. However, current approaches for …
Novel Transcriptomic Mechanisms of Brain Aging
AN Cavalier - 2023 - search.proquest.com
As the world ages, the incidence of age-related diseases like dementia is expected to
increase. Brain aging is characterized by declines in cognitive function that may develop into …
increase. Brain aging is characterized by declines in cognitive function that may develop into …
The Evolution of NF-κB Mediated Transcriptional Regulation in Mammalian Endothelial Cells
L Wang - 2023 - search.proquest.com
NF-κB is an essential and evolutionarily conserved transcription factor complex primarily
involved in innate immunity and inflammation. In the thesis, I explore how the NF-κB-centric …
involved in innate immunity and inflammation. In the thesis, I explore how the NF-κB-centric …