At present, several drug molecules have been used for the treatment of rheumatoid arthritis
(RA). However, the utilization of these compounds through the oral and parenteral route is …

For the past twenty years, chemokines have emerged as a family of critical mediators of cell
migration during immune surveillance, development, inflammation and cancer progression …

Abstract Phosphoinositide 3-kinases (PI3K) have long been considered promising drug
targets for the treatment of inflammatory and autoimmune disorders as well as cancer and …

Rheumatoid arthritis (RA) is one of the most prevalent autoimmune diseases and a
prototypic inflammatory disease, affecting the small joints of the hands and feet. Chemokines …

Evidence suggests that uncontrolled immune system responses and their components play
a significant role in developing rheumatoid arthritis (RA), which is considered an …

Rodent models of rheumatoid arthritis (RA) are useful tools to study the pathogenic process
of RA. Among the most widely used models of RA are the streptococcal cell wall (SCW) …

Rheumatoid arthritis (RA) is a chronic symmetric polyarticular joint disease that primarily
affects the small joints of the hands and feet. The inflammatory process is characterized by …

Class IB phosphatidylinositol 3-kinase p110γ (PI3Kγ) has gained increasing attention as a
promising drug target for the treatment of inflammatory disease. Extensive target-validation …

Celastrol is a bioactive compound derived from traditional Chinese medicinal herbs of the
Celastraceae family. Celastrol is known to possess anti-inflammatory and anti-oxidant …

Rheumatoid arthritis (RA) is a chronic inflammatory disease leading to joint destruction (1).
In RA, migration of leukocytes into the synovial tissue (ST) occurs. These leukocytes and …