Fast synaptic communication in the brain requires synchronous vesicle fusion that is evoked
by action potential-induced Ca2+ influx. However, synaptic terminals also release …

Acute administration of (R, S)-ketamine (ketamine) produces rapid antidepressant effects
that in some patients can be sustained for several days to more than a week. Ketamine …

Synaptic transmission is maintained by a delicate, sub-synaptic molecular architecture, and
even mild alterations in synapse structure drive functional changes during experience …

Clinical studies consistently demonstrate that a single sub-psychomimetic dose of ketamine,
an ionotropic glutamatergic NMDAR (N-methyl-D-aspartate receptor) antagonist, produces …

Scaffolding molecules at the postsynaptic membrane form the foundation of excitatory
synaptic transmission by establishing the architecture of the postsynaptic density (PSD), but …

Systems-level organization in spontaneous infra-slow (< 0.1 Hz) brain activity, measured
using blood oxygen signals in fMRI and optical imaging, has become a major theme in the …

Recent clinical studies have demonstrated that a single subpsychotomimetic dose of
ketamine, an ionotropic glutamatergic N-methyl-d-aspartate (NMDA) receptor antagonist …

Major depressive disorder is a devastating mental disorder. Current antidepressant
medications can be effective for some patients with depression; however, these drugs exert …

Neurotransmitter release from synaptic vesicle fusion is the fundamental mechanism for
neuronal communication at synapses. Evoked release following an action potential has …

Aberrant dopaminergic and glutamatergic function, particularly within the striatum and
hippocampus, has repeatedly been associated with the pathophysiology of schizophrenia …