Background Nonalcoholic fatty liver disease (NAFLD) comprises hepatic alterations with
increased lipid accumulation (steatosis) without or with inflammation (nonalcoholic …

The global epidemic of obesity has been accompanied by a rising burden of non-alcoholic
fatty liver disease (NAFLD), with manifestations ranging from simple steatosis to non …

Non-alcoholic steatohepatitis (NASH) develops from non-alcoholic fatty liver disease
(NAFLD). Currently, around 25% of the population is estimated to have NAFLD, and 25% of …

Background Non-alcoholic fatty liver disease (NAFLD) is defined by the abundance of lipid
droplets (LDs) in hepatocytes. While historically considered simply a depot for energy …

The exposure of hepatocytes to high concentrations of lipids and carbohydrates and the
ensuing hepatocellular injury are termed lipotoxicity and glucotoxicity, respectively. A …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

The pathogenic mechanisms underlying the progression of non-alcoholic fatty liver disease
(NAFLD) are not fully understood. In this study, we aimed to assess the relationship between …

Spermidine is a natural polyamine that has health benefits and extends life span in several
species. Deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxylase (DOHH) are key …

Background and aims Non-alcoholic steatohepatitis (NASH), the potentially progressive
form of nonalcoholic fatty liver disease (NAFLD), is the pandemic liver disease of our time …

At present chronic liver disease (CLD), the third commonest cause of premature death in the
United Kingdom is detected late, when interventions are ineffective, resulting in …