The diabetic brain and cognition

P Riederer, AD Korczyn, SS Ali, O Bajenaru… - Journal of neural …, 2017 - Springer
The prevalence of both Alzheimer's disease (AD) and vascular dementia (VaD) is increasing
with the aging of the population. Studies from the last several years have shown that people …

Management of Alzheimer's disease—An insight of the enzymatic and other novel potential targets

B ul Islam, S Tabrez - International journal of biological macromolecules, 2017 - Elsevier
Alzheimer's disease (AD) is a well-known cause of memory loss and dementia in elderly
people all across the world. It is pathophysiologically characterized by the extracellular …

Interaction study of dietary fibers (pectin and cellulose) with meat proteins using bioinformatics analysis: An In-Silico study

SS Ahmad, M Khalid, K Younis - LWT, 2020 - Elsevier
As meat is deficient in dietary fiber, it is combined with different dietary fibers from cereals,
fruits, and vegetables. Interactions of pectin and cellulose with actin, myosin, and collagen …

Forxiga (dapagliflozin): Plausible role in the treatment of diabetes‐associated neurological disorders

S Shaikh, SMD Rizvi, S Shakil, S Riyaz… - Biotechnology and …, 2016 - Wiley Online Library
Numerous clinical and epidemiological studies have provided direct evidence to strengthen
the link between type 2 diabetes (T2D) and Alzheimer's disease (AD). The possibility that …

Multiple targets for the management of Alzheimer's disease

S Sayeed Ahmad, S Akhtar… - CNS & Neurological …, 2016 - ingentaconnect.com
AD is a progressive and irreversible neurodegenerative disease and the most common
cause of dementia in the elderly population. eta-amyloid cascade formation along with …

[HTML][HTML] Principal Component Analysis (PCA) of Molecular Descriptors for Improving Permeation through the Blood–Brain Barrier of Quercetin Analogues

N Pavlović, N Milošević Sopta, D Mitrović… - International Journal of …, 2023 - mdpi.com
Despite its beneficial pharmacological effects in the brain, partly by modulating inositol
phosphate multikinase (IPMK) activity, the therapeutic use of quercetin is limited due to its …

[HTML][HTML] Molecular interaction of inhibitors with human brain butyrylcholinesterase

S Shakil - EXCLI journal, 2021 - ncbi.nlm.nih.gov
Alzheimer's disease is a topic of deep research interest across the global scientific
community. Butyrylcholinesterase (BuChE) is an important enzyme, and an interesting anti …

(⿿)-Epicatechin derivate from Orostachys japonicus as potential inhibitor of the human butyrylcholinesterase

JH Kim, SH Lee, HW Lee, YN Sun, WH Jang… - International journal of …, 2016 - Elsevier
Cholinesterase inhibitors block the bioconversion of neurotransmitters by cholinesterase in
the nervous system. Epicatechin derivatives (1, 3 and 5), polyphenols (6 and 7) from …

Molecular interaction of cryptophycin 52 with Caspase 8 for the management of lung cancer during coronavirus outbreak: A computational study

LH Bajrai, SS Sohrab, M Khalid, MA Kamal… - Cellular and Molecular …, 2022 - cellmolbiol.org
It has been seen that, during COVID-19 outbreak lung cancer (LC) patients are noted as a
high-risk population which make a more challenging to treatment of the LC patients. The …

Kinetics and Molecular Docking Study of an Anti-diabetic Drug Glimepiride as Acetylcholinesterase Inhibitor: Implication for Alzheimer's Disease-Diabetes Dual …

SMD Rizvi, S Shaikh, D Naaz, S Shakil, A Ahmad… - Neurochemical …, 2016 - Springer
At the present time, treatment of two most common degenerative disorders of elderly
population ie, Type 2 Diabetes Mellitus (T2DM) and Alzheimer's disease (AD) is a major …