Process knowledge for drug substance production via kinetic modeling, parameter estimability analysis and reaction optimization
I Moshiritabrizi, JP McMullen, BM Wyvratt… - Reaction Chemistry & …, 2024 - pubs.rsc.org
A mechanistic model is developed to study the formation of 2, 6-difluoropurine-9-THP from
starting material 2, 6-dichloropurine-9-THP. The 2, 6-difluoropurine-9-THP product is an …
starting material 2, 6-dichloropurine-9-THP. The 2, 6-difluoropurine-9-THP product is an …
Rational scale-up of catalytic hydrogenation involving slowly dissolving reactants
F Nanto, D Ciato, P Canu - Chemical Engineering Science, 2024 - Elsevier
Based on an experimental campaign, a model is developed for scaling up a fed-batch
catalytic hydrogenation, characterized by a slow dissolution of the reagent. The model …
catalytic hydrogenation, characterized by a slow dissolution of the reagent. The model …
Continuous reactor network design for rigid polyol production
In this study, we focus on developing continuous reactor network models able to produce
rigid polyols under strict product and safety specifications. At the same time, we determine …
rigid polyols under strict product and safety specifications. At the same time, we determine …
Parameter estimation and estimability analysis in pharmaceutical models with uncertain inputs
A methodology is proposed to aid parameter estimation in fundamental models of
pharmaceutical processes. This methodology addresses situations with insufficient data to …
pharmaceutical processes. This methodology addresses situations with insufficient data to …
[PDF][PDF] An Optimization Framework for Kinetic Model Building from Concentration and Spectroscopic Data
TJ Krumpolc - 2024 - kilthub.cmu.edu
This dissertation deals with the development of an optimization framework for kinetic model
building from experimentally measured concentration and spectroscopic data. We develop …
building from experimentally measured concentration and spectroscopic data. We develop …