Model systems for regeneration: the spiny mouse, Acomys cahirinus

M Maden, JA Varholick - Development, 2020 - journals.biologists.com
The spiny mouse, Acomys spp., is a recently described model organism for regeneration
studies. For a mammal, it displays surprising powers of regeneration because it does not …

Regeneration in the spiny mouse, Acomys, a new mammalian model

AGW Sandoval, M Maden - Current opinion in genetics & development, 2020 - Elsevier
Highlights•Acomys (spiny mouse) is a newly discovered mammal which can regenerate
several tissues.•The skin regenerates after removal or burn injury and so do ear …

Complex tissue regeneration in mammals is associated with reduced inflammatory cytokines and an influx of T cells

TR Gawriluk, J Simkin, CK Hacker, JM Kimani… - Frontiers in …, 2020 - frontiersin.org
While mammals tend to repair injuries, other adult vertebrates like salamanders and fish
regenerate damaged tissue. One prominent hypothesis offered to explain an inability to …

Xenopus, a model to study wound healing and regeneration: Experimental approaches

PG Slater, M Palacios, J Larraín - Cold Spring Harbor …, 2021 - cshprotocols.cshlp.org
Xenopus has been widely used as a model organism to study wound healing and
regeneration. During early development and at tadpole stages, Xenopus is a quick healer …

Spiny mice (Acomys) exhibit attenuated hallmarks of aging and rapid cell turnover after UV exposure in the skin epidermis

W Wong, A Kim, JR Monaghan, AW Seifert, M Maden… - PloS one, 2020 - journals.plos.org
The study of long-lived and regenerative animal models has revealed diverse protective
responses to stressors such as aging and tissue injury. Spiny mice (Acomys) are a unique …

Healing power: The mammalian macrophage in skeletal regeneration, scar formation, and regenerative medicine

J Simkin, LA Dawson, M Simkin, K Muneoka - Journal of Immunology and …, 2020 - Elsevier
Common to all types of injuries, inflammation is the initial stage of healing. The final outcome
of healing, however, can be quite distinct after different types of injuries. Some tissues, such …