Reproduction involves a wide range of biological processes, including organ formation and
development, neuroendocrine regulation, hormone production, and meiosis and mitosis …

Aging biomarkers are a combination of biological parameters to (i) assess age-related
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …

Premature ovarian insufficiency (POI) affects 1% of women and is a leading cause of
infertility. It is often considered to be a monogenic disorder, with pathogenic variants in~ 100 …

Cerebral palsy (CP) is the most common motor disability in children. To ascertain the role of
major genetic variants in the etiology of CP, we conducted exome sequencing on a large …

Rationale: Premature ovarian insufficiency (POI) is an accelerated reduction in ovarian
function inducing infertility. Folliculogenesis defects have been reported to trigger POI as a …

Premature ovarian insufficiency (POI) is a clinical syndrome of ovarian dysfunction
characterized by cessation of menstruation occurring before the age of 40 years. The …

The decline in fertility in aging women, especially those with poor ovarian response (POR)
or primary ovarian insufficiency (POI), is a major concern for modern IVF centers. Fertility …

Non-steroidal anti-inflammatory drugs (NSAIDs) and 17α-ethinylestradiol (EE2) are
extensively used in human and veterinary medicine. Due to their partial removal by …

Ovarian aging is a major obstacle in assisted reproductive medicine because it leads to
ovarian dysfunction in women of advanced age. Currently, there are no effective treatments …

Premature ovarian insufficiency (POI), also known as premature menopause or premature
ovarian failure, signifies the partial or complete loss of ovarian endocrine function and …