Current discoveries and future implications of eating disorders

B Feng, J Harms, E Chen, P Gao, P Xu… - International Journal of …, 2023 - mdpi.com
Eating disorders (EDs) are characterized by severe disturbances in eating behaviors and
can sometimes be fatal. Eating disorders are also associated with distressing thoughts and …

Eating disorders and obesity: bridging clinical, neurobiological, and therapeutic perspectives

L Camacho-Barcia, KE Giel, S Jiménez-Murcia… - Trends in Molecular …, 2024 - cell.com
Eating disorders (EDs) and obesity are complex health conditions sharing various risk and
maintenance factors, intensified in cases of comorbidity. This review explores the similarities …

Repeated stress triggers seeking of a starvation-like state in anxiety-prone female mice

H Kucukdereli, O Amsalem, T Pottala, M Lim… - Neuron, 2024 - cell.com
Elevated anxiety often precedes anorexia nervosa and persists after weight restoration.
Patients with anorexia nervosa often describe self-starvation as pleasant, potentially …

[HTML][HTML] Hypothalamic volume is associated with body mass index

SSG Brown, ML Westwater, J Seidlitz, H Ziauddeen… - NeuroImage: Clinical, 2023 - Elsevier
The hypothalamus is an important neuroendocrine hub for the control of appetite and satiety.
In animal studies it has been established that hypothalamic lesioning or stimulation causes …

A small-molecule degrader of TET3 as treatment for anorexia nervosa in an animal model

H Lv, J Catarino, D Li, B Liu, XB Gao… - Proceedings of the …, 2023 - National Acad Sciences
Anorexia nervosa (AN) is a psychiatric illness with the highest mortality. Current treatment
options have been limited to psychotherapy and nutritional support, with low efficacy and …

Development of activity-based anorexia requires PKC-δ neurons in two central extended amygdala nuclei

WI Schnapp, JM Kim, Y Wang, S Timilsena, C Fang… - Cell reports, 2024 - cell.com
Anorexia nervosa (AN) is a serious psychiatric disease, but the neural mechanisms
underlying its development are unclear. A subpopulation of amygdala neurons, marked by …

Chronic stress triggers seeking of a starvation-like state in anxiety-prone female mice

H Kucukdereli, O Amsalem, T Pottala, M Lim… - bioRxiv, 2023 - biorxiv.org
Elevated anxiety often precedes anorexia nervosa and persists after weight restoration.
Patients with anorexia nervosa often describe hunger as pleasant, potentially because food …

Microglia are Required for Developmental Specification of AgRP Innervation in the Hypothalamus of Offspring Exposed to Maternal High Fat Diet During Lactation

HN Mendoza-Romero, JE Biddinger… - …, 2024 - pmc.ncbi.nlm.nih.gov
Nutritional fluctuations that occur early in life dictate metabolic adaptations that will affect
susceptibility to weight gain and obesity later in life. The postnatal period in mice represents …

[HTML][HTML] The attenuation of activity-based anorexia by obese adipose tissue transplant is AgRP neuron-dependent

DJ Yoon, J Zhang, RC Zapata, M Ulivieri, AM Libster… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Anorexia nervosa (AN) is an eating disorder observed primarily in girls and women, and is
characterized by a low body mass index, hypophagia, and hyperactivity. The activity-based …

Taking better advantage of the activity-based anorexia model

CJ Foldi - Trends in Molecular Medicine, 2024 - cell.com
The lack of specific treatments for anorexia nervosa (AN) is partly driven by an inadequate
understanding of the neurobiological drivers of the condition. The activity-based anorexia …