The amyloid cascade hypothesis is a useful framework for therapeutic development in
Alzheimer's disease (AD). Amyloid b 1-42 (Aβ) has been the main target of experimental …

Meaningful reductions in racial and ethnic inequities in chronic diseases of aging remain
unlikely without major advancements in the inclusion of minoritized populations in aging …

Abstract The National Institute on Aging and the Alzheimer's Association convened three
separate work groups in 2011 and single work groups in 2012 and 2018 to create …

Importance Disrupted sleep is common in aging and is associated with cognition. Age-
related changes to sleep are associated with multiple causes, including early Alzheimer …

Background and Objectives To evaluate whether plasma biomarkers of amyloid
(Aβ42/Aβ40), tau (p-tau181 and p-tau231), and neuroaxonal injury (neurofilament light …

Importance Racial and ethnic groups with higher rates of clinical Alzheimer disease (AD) are
underrepresented in studies of AD biomarkers, including amyloid positron emission …

Background and Objectives Treatment options for Alzheimer disease (AD) are limited and
have focused mainly on symptomatic therapy and improving quality of life. Recently …

Background and Objectives Recent advances in blood-based biomarkers offer the potential
to revolutionize the diagnosis and management of Alzheimer disease (AD), but additional …

Health Disparities in Dementia : CONTINUUM: Lifelong Learning in Neurology Account Register
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Availability of safe and effective treatmentsfor Alzheimer disease is an urgent challenge
given the global shift toward an older population and increased risk of mild cognitive …