The limb is a commonly used model system for developmental biology. Given the need for
precise control of complex signalling pathways to achieve proper patterning, the limb is also …

The p53 protein family is the most studied protein family of all. Sequence analysis and
structure determination have revealed a high similarity of crucial domains between p53, p63 …

The mechanisms by which the p53 tumor suppressor acts remain incompletely understood.
To gain new insights into p53 biology, we used high-throughput sequencing to analyze …

The human body contains thousands of unique cell types, each with specialized functions.
Cell identity is governed in large part by gene transcription programs, which are determined …

Dynamic reprogramming of gene regulatory networks (GRNs) enables organisms to rapidly
respond to environmental perturbation. However, the underlying transient interactions …

Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) represent two classes of
important non-coding RNAs in eukaryotes. Although these non-coding RNAs have been …

The transcription factor p63 is important in the development of the skin as p63-null mice
exhibit striking defects in embryonic epidermal morphogenesis. Understanding the …

Emerging evidence suggests that cancer is populated and maintained by tumour-initiating
cells (TICs) with stem-like properties similar to those of adult tissue stem cells. Despite …

Enhancers are essential gene regulatory elements whose alteration can lead to
morphological differences between species, developmental abnormalities, and human …

Disrupted epidermal differentiation characterizes numerous diseases that impact> 25% of
the population. In a search for dominant mediators of differentiation, we defined a …