Triazavirin—A novel effective antiviral drug
ON Chupakhin, VL Rusinov, MV Varaksin… - International Journal of …, 2022 - mdpi.com
This review outlines the data of numerous studies relating to the broad-spectrum antiviral
drug Triazavirin that was launched on the Russian pharmaceutical market in 2014 as an anti …
drug Triazavirin that was launched on the Russian pharmaceutical market in 2014 as an anti …
QSAR, molecular docking and ADMET properties in silico studies of novel 4, 5, 6, 7-tetrahydrobenzo [D]-thiazol-2-Yl derivatives derived from dimedone as potent anti …
A quantitative structure-activity relationship (QSAR) study is performed on 48 novel 4, 5, 6, 7-
tetrahydrobenzo [D]-thiazol-2 derivatives as anticancer agents capable of inhibiting c-Met …
tetrahydrobenzo [D]-thiazol-2 derivatives as anticancer agents capable of inhibiting c-Met …
Identification of potent and safe antiviral therapeutic candidates against SARS-CoV-2
X Xiao, C Wang, D Chang, Y Wang, X Dong… - Frontiers in …, 2020 - frontiersin.org
COVID-19 pandemic has infected millions of people with mortality exceeding> 1 million.
There is an urgent need to find therapeutic agents that can help clear the virus to prevent …
There is an urgent need to find therapeutic agents that can help clear the virus to prevent …
Repurposing Anticancer Drugs Targeting the MAPK/ERK Signaling Pathway for the Treatment of Respiratory Virus Infections
Y Liu, Z Luo - International Journal of Molecular Sciences, 2024 - mdpi.com
Respiratory virus infections remain a significant challenge to human health and the social
economy. The symptoms range from mild rhinitis and nasal congestion to severe lower …
economy. The symptoms range from mild rhinitis and nasal congestion to severe lower …
Combined molecular docking and dynamics simulations studies of natural compounds as potent inhibitors against SARS-CoV-2 main protease
Main protease (Mpro) of SARS-CoV-2 is a key CoV enzyme that plays a pivotal role in
mediating viral replication and transcription, making it an attractive drug target for SARS …
mediating viral replication and transcription, making it an attractive drug target for SARS …
Cyclohexane-1, 3-dione derivatives as future therapeutic agents for NSCLC: QSAR modeling, in silico ADME-Tox properties, and structure-based drug designing …
The abnormal expression of the c-Met tyrosine kinase has been linked to the proliferation of
several human cancer cell lines, including non-small-cell lung cancer (NSCLC). In this …
several human cancer cell lines, including non-small-cell lung cancer (NSCLC). In this …
Design of novel benzimidazole derivatives as potential α-amylase inhibitors using QSAR, pharmacokinetics, molecular docking, and molecular dynamics simulation …
In the present study, a quantitative relationship between the biological inhibitory activity of
alpha-amylase and molecular structures of novel benzimidazole derivatives is analyzed in …
alpha-amylase and molecular structures of novel benzimidazole derivatives is analyzed in …
Salmonella effector SopB reorganizes cytoskeletal vimentin to maintain replication vacuoles for efficient infection
S Zhao, Q Xu, Y Cui, S Yao, S Jin, Q Zhang… - Nature …, 2023 - nature.com
A variety of intracellular bacteria modulate the host cytoskeleton to establish subcellular
niches for replication. However, the role of intermediate filaments, which are crucial for …
niches for replication. However, the role of intermediate filaments, which are crucial for …
Cameroonian medicinal plants as potential candidates of SARS-CoV-2 inhibitors
RT Fouedjou, S Chtita, M Bakhouch… - Journal of …, 2022 - Taylor & Francis
Abstract Coronavirus disease 2019 (COVID-19) is an ongoing pandemic instigated by
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) which changed the daily …
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) which changed the daily …
[HTML][HTML] Unsymmetrical aromatic disulfides as SARS-CoV-2 Mpro inhibitors: Molecular docking, molecular dynamics, and ADME scoring investigations
COVID-19 pandemic caused by very severe acute respiratory syndrome coronavirus-2
(SARS-CoV-2) agent is an ongoing major global health concern. The disease has caused …
(SARS-CoV-2) agent is an ongoing major global health concern. The disease has caused …