Functions of galanin, spexin and kisspeptin in metabolism, mood and behaviour

EG Mills, C Izzi-Engbeaya, A Abbara… - Nature Reviews …, 2021 - nature.com
The bioactive peptides galanin, spexin and kisspeptin have a common ancestral origin and
their pathophysiological roles are increasingly the subject of investigation. Evidence …

Adipose–Muscle crosstalk in age-related metabolic disorders: The emerging roles of adipo-myokines

P Fang, Y She, M Yu, W Min, W Shang… - Ageing Research Reviews, 2023 - Elsevier
Obesity and type 2 diabetes account for a considerable proportion of the global burden of
age-related metabolic diseases. In age-related metabolic diseases, tissue crosstalk and …

Assessment of acute aerobic exercise in the morning versus evening on asprosin, spexin, lipocalin-2, and insulin level in overweight/obese versus normal weight …

Hİ Ceylan, Ö Saygın, Ü Özel Türkcü - Chronobiology International, 2020 - Taylor & Francis
The aim of this study was to examine the acute effect of aerobic exercise when performed in
the morning and evening on obesity-related hormones of asprosin, spexin, lipocalin-2, and …

Emerging roles of NPQ/spexin in physiology and pathology

SY Lv, YC Zhou, XM Zhang, WD Chen… - Frontiers in …, 2019 - frontiersin.org
Spexin (SPX), also called neuropeptide Q (NPQ), is a novel endogenous neuropeptide.
Spexin gene and protein are widely expressed in central nervous system and peripheral …

Spexin as an indicator of beneficial effects of exercise in human obesity and diabetes

A Khadir, S Kavalakatt, D Madhu, S Devarajan… - Scientific reports, 2020 - nature.com
Spexin is a novel neuropeptide playing an emerging role in metabolic diseases such as
obesity and diabetes via involvement in energy homeostasis and food intake. The present …

Different spexin level in obese vs normal weight children and its relationship with obesity related risk factors

M Behrooz, E Vaghef-Mehrabany… - Nutrition, Metabolism and …, 2020 - Elsevier
Background and aims Spexin (SPX) is a novel peptide recently discovered as an important
regulatory adipokine in obesity and related metabolic diseases. The aim of the current study …

The role of spexin in energy metabolism

X Sun, Z Yu, Y Xu, S Pu, X Gao - Peptides, 2023 - Elsevier
Spexin, also identified as neuropeptide Q (NPQ), is a 14 amino acid peptide discovered by
bioinformatic methods. It has a conserved structure in many species and is widely expressed …

Spexin improves adipose tissue inflammation and macrophage recruitment in obese mice

SE Gambaro, MG Zubiría, AP Giordano… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Spexin (SPX) is a novel adipokine related to many metabolic effects, such as gastrointestinal
movements, insulin and glucose homeostasis, lipid metabolism and energy balance. This …

Novel insights on the role of spexin as a biomarker of obesity and related cardiometabolic disease

S Kumar, RT Mankowski, SD Anton… - International Journal of …, 2021 - nature.com
Abstract Spexin (SPX) is a 14-amino acid neuropeptide, discovered recently using
bioinformatic techniques. It is encoded by the Ch12: orf39 gene that is widely expressed in …

Spexin: Its role, regulation, and therapeutic potential in the hypothalamus

A Tran, W He, JTC Chen, DD Belsham - Pharmacology & therapeutics, 2022 - Elsevier
Spexin is the most recently discovered member of the galanin/kisspeptin/spexin family of
peptides. This 14-amino acid peptide is highly conserved and is implicated in homeostatic …