New insights into activation and function of the AMPK
GR Steinberg, DG Hardie - Nature reviews Molecular cell biology, 2023 - nature.com
The classical role of AMP-activated protein kinase (AMPK) is as a cellular energy sensor
activated by falling energy status, signalled by increases in AMP to ATP and ADP to ATP …
activated by falling energy status, signalled by increases in AMP to ATP and ADP to ATP …
AMPK and TOR: the yin and yang of cellular nutrient sensing and growth control
The AMPK (AMP-activated protein kinase) and TOR (target-of-rapamycin) pathways are
interlinked, opposing signaling pathways involved in sensing availability of nutrients and …
interlinked, opposing signaling pathways involved in sensing availability of nutrients and …
AMPK: sensing glucose as well as cellular energy status
Mammalian AMPK is known to be activated by falling cellular energy status, signaled by
rising AMP/ATP and ADP/ATP ratios. We review recent information about how this occurs …
rising AMP/ATP and ADP/ATP ratios. We review recent information about how this occurs …
AKT/PKB signaling: navigating the network
BD Manning, A Toker - Cell, 2017 - cell.com
The Ser and Thr kinase AKT, also known as protein kinase B (PKB), was discovered 25
years ago and has been the focus of tens of thousands of studies in diverse fields of biology …
years ago and has been the focus of tens of thousands of studies in diverse fields of biology …
[HTML][HTML] Cellular senescence in cardiovascular diseases: a systematic review
C Hu, X Zhang, T Teng, ZG Ma, QZ Tang - Aging and disease, 2022 - ncbi.nlm.nih.gov
Aging is a prominent risk factor for cardiovascular diseases, which is the leading cause of
death around the world. Recently, cellular senescence has received potential attention as a …
death around the world. Recently, cellular senescence has received potential attention as a …
ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway
Y Zhao, X Hu, Y Liu, S Dong, Z Wen, W He, S Zhang… - Molecular cancer, 2017 - Springer
Cancer cells are frequently confronted with metabolic stress in tumor microenvironments
due to their rapid growth and limited nutrient supply. Metabolic stress induces cell death …
due to their rapid growth and limited nutrient supply. Metabolic stress induces cell death …
AMPK as a therapeutic target for treating metabolic diseases
EA Day, RJ Ford, GR Steinberg - Trends in Endocrinology & Metabolism, 2017 - cell.com
The AMP-activated protein kinase (AMPK) is a central regulator of multiple metabolic
pathways and may have therapeutic importance for treating obesity, insulin resistance, type …
pathways and may have therapeutic importance for treating obesity, insulin resistance, type …
[HTML][HTML] Exercise and dietary intervention ameliorate high-fat diet-induced NAFLD and liver aging by inducing lipophagy
Y Gao, W Zhang, LQ Zeng, H Bai, J Li, J Zhou, GY Zhou… - Redox biology, 2020 - Elsevier
Exercise and dietary intervention are currently available strategies to treat nonalcoholic fatty
liver disease (NAFLD), while the underlying mechanism remains controversial. Emerging …
liver disease (NAFLD), while the underlying mechanism remains controversial. Emerging …
The upstream pathway of mTOR-mediated autophagy in liver diseases
H Wang, Y Liu, D Wang, Y Xu, R Dong, Y Yang, Q Lv… - Cells, 2019 - mdpi.com
Autophagy, originally found in liver experiments, is a cellular process that degrades
damaged organelle or protein aggregation. This process frees cells from various stress …
damaged organelle or protein aggregation. This process frees cells from various stress …
AMPK—sensing energy while talking to other signaling pathways
DG Hardie - Cell metabolism, 2014 - cell.com
The AMP-activated protein kinase (AMPK) is a sensor of cellular energy and nutrient status,
expressed almost universally in eukaryotes as heterotrimeric complexes comprising catalytic …
expressed almost universally in eukaryotes as heterotrimeric complexes comprising catalytic …