Simple Summary All cells are covered in a thick layer of sugar molecules known as glycans.
Changes to this sugar coat are common in cancer, and in particular cancer cells often …

Abstract Acetyl-coenzyme A (Ac-CoA) is a core metabolite with essential roles throughout
cell physiology. These functions can be classified into energetics, biosynthesis, regulation …

O-acetylation is a common modification of sialic acids that has been implicated in a
multitude of biological and disease processes. A lack of analytical methods that can …

Despite the versatility of enzyme-mediated oligosaccharide assembly, it has as a limitation
that not all glycosyl transferases or glycan-modifying enzymes are readily available to install …

The immunomodulatory family of Siglecs recognizes sialic acid-containing glycans as “self”,
which is exploited in cancer for immune evasion. The biochemical nature of Siglec ligands …

The asialoglycoprotein receptor (ASGPR) and the mannose receptor C-type 1 (MRC1) are
well known for their selective recognition and clearance of circulating glycoproteins …

Acetyl-coenzyme A (acetyl-CoA), an essential metabolite, not only takes part in numerous
intracellular metabolic processes, powers the tricarboxylic acid cycle, serves as a key hub …

Sialic acid is a kind of monosaccharide expressed on the non-reducing end of glycoproteins
or glycolipids. It acts as a signal molecule combining with its natural receptors such as …

In order to establish malignant lesions, tumors must first evade their detection by immune
cells. Tumors achieve this by embellishing and tailoring their glycocalyx, a network of …

Influenza D virus (IDV) utilizes bovines as a primary reservoir with periodical spillover to
other hosts. We have previously demonstrated that IDV binds both 9-O-acetylated N …