Nonhomologous DNA end-joining (NHEJ) is the predominant double-strand break (DSB)
repair pathway throughout the cell cycle and accounts for nearly all DSB repair outside of …

Nonhomologous end joining (NHEJ) refers to a set of genome maintenance pathways in
which two DNA double-strand break (DSB) ends are (re) joined by apposition, processing …

Genomic DNA is susceptible to endogenous and environmental stresses that modify DNA
structure and its coding potential. Correspondingly, cells have evolved intricate DNA repair …

Even though high-fidelity polymerases copy DNA with remarkable accuracy, some base-pair
mismatches are incorporated at low frequency, leading to spontaneous mutagenesis. Using …

Nearly every DNA polymerase characterized to date exclusively catalyzes the incorporation
of mononucleotides into a growing primer using a DNA or RNA template as a guide to direct …

Cells throughout nature contain multiple and overlapping DNA repair pathways that are
essential for maintaining the integrity of genomic DNA. 1, 2 The DNA repair pathway known …

To maintain genomic stability, ribonucleotide incorporation during DNA synthesis is
controlled predominantly at the DNA polymerase level. A steric clash between the 2 …

The molecular details of the nucleotidyl transferase reaction have remained speculative, as
strategies to trap catalytic intermediates for structure determination utilize substrates lacking …

DNA polymerase ɛ (Pol ɛ) is a high-fidelity polymerase that has been shown to participate
in leading-strand synthesis during DNA replication in eukaryotic cells. We present here a …

The efficient removal of replication and recombination intermediates is essential for the
maintenance of genome stability. Resolution of these potentially toxic structures requires the …