Advancements in gelatin-based hydrogel systems for biomedical applications: a state-of-the-art review

S Mohanto, S Narayana, KP Merai, JA Kumar… - International Journal of …, 2023 - Elsevier
A gelatin-based hydrogel system is a stimulus-responsive, biocompatible, and
biodegradable polymeric system with solid-like rheology that entangles moisture in its …

Advances in the development of nano-engineered mechanically robust hydrogels for minimally invasive treatment of bone defects

K Kaur, CM Murphy - Gels, 2023 - mdpi.com
Injectable hydrogels were discovered as attractive materials for bone tissue engineering
applications given their outstanding biocompatibility, high water content, and versatile …

Tuning of Mechanical Properties in Photopolymerizable Gelatin-Based Hydrogels for In Vitro Cell Culture Systems

R Pamplona, S González-Lana, P Romero… - ACS Applied Polymer …, 2023 - ACS Publications
The mechanical microenvironment plays a crucial role in the evolution of colorectal cancer,
a complex disease characterized by heterogeneous tumors with varying elasticity. Toward …

Antiviral supramolecular polymeric hydrogels by self-assembly of tenofovir-bearing peptide amphiphiles

MK Monroe, H Wang, CF Anderson, M Qin… - Biomaterials …, 2023 - pubs.rsc.org
The development of long-acting antiviral therapeutic delivery systems is crucial to improve
the current treatment and prevention of HIV and chronic HBV. We report here on the …

Supramolecular presentation of bioinstructive peptides on soft multilayered nanobiomaterials stimulates neurite outgrowth

M Lopes, M Torrado, D Barth, SD Santos… - Biomaterials …, 2023 - pubs.rsc.org
Peptide amphiphiles (PAs) have emerged as effective molecular building blocks for creating
self-assembling nanobiomaterials for multiple biomedical applications. Herein, we report a …

Human periodontal ligament stem cells-derived exosomes-loaded hybrid hydrogel enhances the calvarial defect regeneration in middle-age rats

M Isik, I Vargel, E Ozgur, SB Cam, P Korkusuz… - Materials Today …, 2023 - Elsevier
Advances in bone tissue engineering through integrating biologically active extracellular
nanovesicles with biomaterial platforms offer a promising solution to overcome the reduced …

Unveiling the versatility of gelatin methacryloyl hydrogels: a comprehensive journey into biomedical applications

S Pramanik, M Alhomrani, AS Alamri… - Biomedical …, 2024 - iopscience.iop.org
Gelatin methacryloyl (GelMA) hydrogels have gained significant recognition as versatile
biomaterials in the biomedical domain. GelMA hydrogels emulate vital characteristics of the …

Omics technologies for high-throughput-screening of cell–biomaterial interactions

B Sari, M Isik, CC Eylem, C Bektas, BO Okesola… - Molecular …, 2022 - pubs.rsc.org
Recent research effort in biomaterial development has largely focused on engineering bio-
instructive materials to stimulate specific cell signaling. Assessing the biological …

Bioactive and chemically defined hydrogels with tunable stiffness guide cerebral organoid formation and modulate multi-omics plasticity in cerebral organoids

M Isik, BO Okesola, CC Eylem, E Kocak, E Nemutlu… - Acta Biomaterialia, 2023 - Elsevier
Organoids are an emerging technology with great potential in human disease modelling,
drug development, diagnosis, tissue engineering, and regenerative medicine. Organoids as …

Capecitabine-loaded bacterial membrane vesicles derived from Enterococcus faecalis promotes apoptosis in HT-29 colon cancer cells

KE Gover, M Isik, D Barut, CT Sengel-Turk… - Biochemical …, 2022 - Elsevier
Bacterial membrane vesicles have recently attracted attention as drug delivery systems for
antineoplastic agents to target cancerous cells and reduce the side effects of free cytostatic …