The Notch pathway is often regarded as a developmental pathway, but components of Notch
signalling are expressed and active in the adult brain. With the advent of more sophisticated …

Dendrite morphogenesis is a complex but well-orchestrated process and includes the
development of dendritic branches, forming characteristic dendrite arbors, and dendritic …

The nuclear factor-kappa B (NF-κB) family of transcription factors has recently emerged as a
major regulator of the growth and elaboration of neural processes. NF-κB signaling has …

The nervous system is a target and a source of steroids. Neuroactive steroids are steroids
that target neurons and glial cells. They include hormonal steroids originated in the …

The establishment of functional neural connections requires the growth of axons to specific
target areas and the formation of synapses with appropriate synaptic partners. Several …

In the nervous system, Notch pathway has a prominent role in the control of neuronal
morphology and in the determination of the astrocyte fate. However, the role of Notch in …

Presenilins (PSs) are the catalytic core of γ-secretase complex. However, the mechanism of
FAD-associated PS mutations in AD pathogenesis still remains elusive. Here we review the …

Neurotrophin stimulation of tropomyosin‐related kinase (Trk) and p75 receptors influences
cellular processes such as proliferation, growth, differentiation, and other cell‐specific …

Tumour necrosis factor-α (TNFα) is a pro-inflammatory cytokine, which influences neuronal
survival and function yet there is limited information available on its effects on hippocampal …

The cerebral cortex undergoes rapid folding in an “inside-outside” manner during embryonic
development resulting in the establishment of six discrete cortical layers. This unique …