Cancer treatment faces many hurdles and resistance is one among them. Anti-cancer
treatment strategies are evolving due to innate and acquired resistance capacity, governed …

Simple Summary Tyrosine kinase inhibitors (TKIs) have demonstrated effectiveness in a
variety of malignancies. As is the case for many different classes of drugs, tyrosine kinase …

Non-small cell lung cancer (NSCLC) adenocarcinoma (LUAD) is a leading cause of death
worldwide. Activating mutations in the tyrosine kinase domain of the oncogene epidermal …

To improve the coverage in bottom-up proteomics, S-aminoethylation of cysteine residues
(AE-Cys) was carried out with 2-bromoethylamine, followed by cleavage with lysyl …

Lung cancer is a leading cause of mortality worldwide, especially among Asian patients with
non-small cell lung cancer (NSCLC) who have epidermal growth factor receptor (EGFR) …

Leptomeningeal carcinomatosis (LMC) is a devastating complication of advanced cancers,
such as lung cancer and breast cancer, which is usually indicative of a poor prognosis. The …

Gefitinib (GET) is a revolutionary targeted treatment inhibiting the epidermal growth factor
receptor's tyrosine kinase action by competitively inhibiting the ATP binding site. In …

Simultaneous inhibition of multiple oncogenic signaling pathways is crucial for managing
refractory cancers. This study introduces two unique core-shell nanoparticle (CS-NP) …

Abstract OSCC (Oral Squamous Cell Carcinoma) occurs in the oral mucosa and is a
prevalent head and neck malignancy, accounting for about 90% of oral cancers. According …

Трансформація аденокарциноми в дрібноклітинний рак легенів як один і Page 1 84
Pathologia. Volume 21. No. 1, January – April 2024 ISSN http://pat.zsmu.edu.ua Трансформація …