CD8+ T cells in HIV control, cure and prevention
HIV infection can be effectively treated by lifelong administration of combination antiretroviral
therapy, but an effective vaccine will likely be required to end the HIV epidemic. Although the …
therapy, but an effective vaccine will likely be required to end the HIV epidemic. Although the …
Past, present and future: 30 years of HIV research
F Barré-Sinoussi, AL Ross, JF Delfraissy - Nature Reviews Microbiology, 2013 - nature.com
This year marks the thirtieth anniversary of the publication of the study that first reported the
isolation of HIV-1. In this Timeline article, we provide a historical perspective of some of the …
isolation of HIV-1. In this Timeline article, we provide a historical perspective of some of the …
Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI Study
Combination antiretroviral therapy (cART) reduces HIV-associated morbidities and
mortalities but cannot cure the infection. Given the difficulty of eradicating HIV-1, a functional …
mortalities but cannot cure the infection. Given the difficulty of eradicating HIV-1, a functional …
Stimulation of HIV-1-specific cytolytic T lymphocytes facilitates elimination of latent viral reservoir after virus reactivation
Highly active antiretroviral therapy (HAART) suppresses HIV-1 replication but cannot
eliminate the virus because HIV-1 establishes latent infection. Interruption of HAART leads …
eliminate the virus because HIV-1 establishes latent infection. Interruption of HAART leads …
TOX is expressed by exhausted and polyfunctional human effector memory CD8+ T cells
T Sekine, A Perez-Potti, S Nguyen, JB Gorin… - Science …, 2020 - science.org
CD8+ T cell exhaustion is a hallmark of many cancers and chronic infections. In mice, T cell
factor 1 (TCF-1) maintains exhausted CD8+ T cell responses, whereas thymocyte selection …
factor 1 (TCF-1) maintains exhausted CD8+ T cell responses, whereas thymocyte selection …
Restriction factors: from intrinsic viral restriction to shaping cellular immunity against HIV-1
M Colomer-Lluch, A Ruiz, A Moris… - Frontiers in …, 2018 - frontiersin.org
Antiviral restriction factors are host cellular proteins that constitute a first line of defense
blocking viral replication and propagation. In addition to interfering at critical steps of the …
blocking viral replication and propagation. In addition to interfering at critical steps of the …
Modeling the within-host dynamics of HIV infection
AS Perelson, RM Ribeiro - BMC biology, 2013 - Springer
The new field of viral dynamics, based on within-host modeling of viral infections, began with
models of human immunodeficiency virus (HIV), but now includes many viral infections …
models of human immunodeficiency virus (HIV), but now includes many viral infections …
Human immunodeficiency virus controllers: mechanisms of durable virus control in the absence of antiretroviral therapy
Chronic viral infections can appear in two very different forms: those that are typically
immunologically contained after acute symptomatic infection, such as Epstein-Barr virus …
immunologically contained after acute symptomatic infection, such as Epstein-Barr virus …
Viral and host mediators of non-suppressible HIV-1 viremia
Abstract Non-suppressible HIV-1 viremia (NSV) is defined as persistent low-level viremia on
antiretroviral therapy (ART) without evidence of ART non-adherence or significant drug …
antiretroviral therapy (ART) without evidence of ART non-adherence or significant drug …
Lytic granule loading of CD8+ T cells is required for HIV-infected cell elimination associated with immune control
SA Migueles, CM Osborne, C Royce, AA Compton… - Immunity, 2008 - cell.com
Virus-specific CD8+ T cells probably mediate control over HIV replication in rare individuals,
termed long-term nonprogressors (LTNPs) or elite controllers. Despite extensive …
termed long-term nonprogressors (LTNPs) or elite controllers. Despite extensive …