[HTML][HTML] Fundus-controlled perimetry (microperimetry): application as outcome measure in clinical trials

M Pfau, JK Jolly, Z Wu, J Denniss, EM Lad… - Progress in Retinal and …, 2021 - Elsevier
Fundus-controlled perimetry (FCP, also called 'microperimetry') allows for spatially-resolved
mapping of visual sensitivity and measurement of fixation stability, both in clinical practice as …

Clinical perspectives and trends: microperimetry as a trial endpoint in retinal disease

Y Yang, H Dunbar - Ophthalmologica, 2021 - karger.com
Endpoint development trials are underway across the spectrum of retinal disease. New
validated endpoints are urgently required for the assessment of emerging gene therapies …

Scotopic microperimetry: evolution, applications and future directions

LJ Taylor, AS Josan, M Pfau… - Clinical and …, 2022 - Taylor & Francis
For many inherited and acquired retinal diseases, reduced night vision is a primary
symptom. Despite this, the clinical testing options for spatially resolved scotopic vision have …

Pentosan Polysulfate Maculopathy: Final Outcomes from a 4-Year Prospective Study of Disease Progression after Drug Cessation

BP Hall, S Shiromani, EH Jung, RJ Lyons… - American Journal of …, 2024 - Elsevier
Purpose To report the long-term disease course of pentosan polysulfate (PPS) maculopathy
following drug cessation. Design Single-institution, prospective case series. Methods 23 …

Exploring Scotopic Microperimetry as an Outcome Measure in Choroideremia

LJ Taylor, AS Josan, D Adeyoju, JK Jolly… - … Vision Science & …, 2024 - tvst.arvojournals.org
Purpose: Choroideremia is an X-linked outer retinal degeneration. Early symptoms include
nyctalopia and progressive visual field loss, but visual acuity is preserved until late disease …

Hypomorphic CDHR1 variants may result in retinitis pigmentosa with relative preservation of cone function

S Farag, IH Yusuf, M Kaukonen, LJ Taylor… - Ophthalmic …, 2024 - Taylor & Francis
Purpose Retinitis pigmentosa (RP) associated with biallelic variants in CDHR1 has rarely
been reported, and detailed phenotyping data are not available. RP implies relative …

Assessment of scotopic function in rod–cone inherited retinal degeneration with the scotopic macular integrity assessment

JK Jolly, A Nanda, TMW Buckley, M Pfau… - … Vision Science & …, 2023 - tvst.arvojournals.org
Purpose: The scotopic macular integrity assessment (S-MAIA) can perform scotopic
assessment to detect localized changes to scotopic rod and cone function. This study is an …

Macular Telangiectasia type 2: multimodal assessment of retinal function and microstructure

AA Ledolter, R Ristl, AM Palmowski‐Wolfe… - Acta …, 2022 - Wiley Online Library
Purpose To assess the impact of neurodegenerative morphologic alterations due to macular
telangiectasia type 2 (MacTel) on microperimetry (MP) and multifocal electroretinography …

Impairments in cone pigment regeneration and absolute threshold in macular telangiectasia type 2

MP Simunovic, K Hess, MC Gillies - Retina, 2022 - journals.lww.com
Purpose: To test the hypothesis that Müller cell dysfunction in macular telangiectasia type 2
(MacTel) results in delayed cone adaptation kinetics and to assess absolute cone and rod …

Dark adaptation in macular telangiectasia type 2

S Tzaridis, K Hess, TFC Heeren, J Nadal, C Mai… - Retina, 2020 - journals.lww.com
Purpose: To evaluate dark adaptation (DA) in patients with macular telangiectasia Type 2
(MacTel). Methods: After a local photobleach (4× 4 size, 83% bleach), DA was measured …