Background: Revision of the guidelines on the use of skin biopsy in the diagnosis of
peripheral neuropathy, published in 2005, has become appropriate owing to publication of …

Abstract Small-fibre neuropathy (SFN), a disorder of thinly myelinated Aδ-fibres and
unmyelinated C-fibres, is clinically characterized by neuropathic pain symptoms and …

Fibromyalgia syndrome is a clinically well-characterized chronic pain condition of high socio-
economic impact. Although the pathophysiology is still unclear, there is increasing evidence …

Objective To assess patterns and impact of small nerve fiber dysfunction and pathology in
patients with fibromyalgia syndrome (FMS). Methods One hundred seventeen women with …

Background: Intraepidermal nerve fiber density (IENFD) is considered a good diagnostic tool
for small fiber neuropathy (SFN). Objectives: To assess stratified normative values for IENFD …

Technical advances are rapidly changing the clinical and instrumental approach to
peripheral nerve diseases. Magnetic resonance neurography, diffusion tensor imaging and …

SFN represents a distinct condition encountered in patients with different acquired and
genetic disorders. The recent improved definition of clinical and skin biopsy criteria allows …

Skin biopsy has become an accepted tool for investigating small nerve fibres, which are
invisible to conventional neurophysiological tests even though they are affected early on in …

The clinical spectrum of small fiber neuropathy (SFN) encompasses manifestations related
to the involvement of thinly myelinated A‐delta and unmyelinated C fibers, including not only …

Laser-evoked potentials are the most extensively validated method to objectively assess
nociceptive pathway function in humans. Here, we review merits and shortcomings of …