In contrast to the multiple disease-modifying therapies that are available for relapsing–
remitting multiple sclerosis (MS), the therapeutic options for progressive MS (PMS) are …

Microglia are implicated in all stages of multiple sclerosis (MS). Microglia alterations are
detected by positron emission tomography in people living with MS prior to the formation of …

Iron fine-tunes innate immune responses, including macrophage inflammation. In this
review, we summarize the current understanding about the iron in dictating macrophage …

The current rate of population growth is so fast that, to feed this massive population, a 2-fold
increase in land is required for the production of quality food. Improved dietary products …

Iron is an essential element involved in a multitude of bodily processes. It is tightly regulated,
as elevated deposition in tissues is associated with diseases such as multiple sclerosis …

Multiple sclerosis (MS) is an immune-mediated disease that targets the myelin sheath of
central nervous system (CNS) neurons leading to axon injury, neuronal death, and …

Established by brain endothelial cells, the blood–brain barrier (BBB) regulates the trafficking
of molecules, restricts immune cell entry into the CNS, and has an active role in …

Potentially toxic elements such as lead and aluminium have been proposed to play a role in
the pathogenesis of multiple sclerosis (MS), since their neurotoxic mechanisms mimic many …

There is increasing evidence that deregulation of metals contributes to a vast range of
neurodegenerative diseases including multiple sclerosis (MS). MS is a chronic inflammatory …

Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease involving
immune-mediated damage. Iron deposition in deep gray matter (DGM) structures like the …