DICER1: mutations, microRNAs and mechanisms
WD Foulkes, JR Priest, TF Duchaine - Nature Reviews Cancer, 2014 - nature.com
Dicer is central to microRNA-mediated silencing and several other RNA interference
phenomena that are profoundly embedded in cancer gene networks. Most recently, both …
phenomena that are profoundly embedded in cancer gene networks. Most recently, both …
Finding function in novel targets: C. elegans as a model organism
T Kaletta, MO Hengartner - Nature reviews Drug discovery, 2006 - nature.com
Despite its apparent simplicity, the nematode worm Caenorhabditis elegans has developed
into an important model for biomedical research, particularly in the functional …
into an important model for biomedical research, particularly in the functional …
Site-specific DICER and DROSHA RNA products control the DNA-damage response
Non-coding RNAs (ncRNAs) are involved in an increasingly recognized number of cellular
events 1. Some ncRNAs are processed by DICER and DROSHA RNases to give rise to …
events 1. Some ncRNAs are processed by DICER and DROSHA RNases to give rise to …
[HTML][HTML] Neuronal small RNAs control behavior transgenerationally
R Posner, IA Toker, O Antonova, E Star, S Anava… - Cell, 2019 - cell.com
It is unknown whether the activity of the nervous system can be inherited. In Caenorhabditis
elegans nematodes, parental responses can transmit heritable small RNAs that regulate …
elegans nematodes, parental responses can transmit heritable small RNAs that regulate …
Origins and diversification of animal innate immune responses against viral infections
Immune systems are of pivotal importance to any living organism on Earth, as they protect
the organism against deleterious effects of viral infections. Though the current knowledge …
the organism against deleterious effects of viral infections. Though the current knowledge …
A Co-CRISPR Strategy for Efficient Genome Editing in Caenorhabditis elegans
H Kim, T Ishidate, KS Ghanta, M Seth, D Conte Jr… - Genetics, 2014 - academic.oup.com
Genome editing based on CRISPR (clustered regularly interspaced short palindromic
repeats)-associated nuclease (Cas9) has been successfully applied in dozens of diverse …
repeats)-associated nuclease (Cas9) has been successfully applied in dozens of diverse …
[HTML][HTML] Transcriptional control of gene expression by microRNAs
MicroRNAs (miRNAs) control gene expression in animals and plants. Like another class of
small RNAs, siRNAs, they affect gene expression posttranscriptionally. While siRNAs in …
small RNAs, siRNAs, they affect gene expression posttranscriptionally. While siRNAs in …
A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment
Abstract miRNA populations, including mammalian homologues of lin-4 (mir-125) and let-7,
undergo a marked transition during stem-cell differentiation. Originally identified on the basis …
undergo a marked transition during stem-cell differentiation. Originally identified on the basis …
[HTML][HTML] Large-scale sequencing reveals 21U-RNAs and additional microRNAs and endogenous siRNAs in C. elegans
We sequenced∼ 400,000 small RNAs from Caenorhabditis elegans. Another 18 microRNA
(miRNA) genes were identified, thereby extending to 112 our tally of confidently identified …
(miRNA) genes were identified, thereby extending to 112 our tally of confidently identified …
[HTML][HTML] Distinct argonaute-mediated 22G-RNA pathways direct genome surveillance in the C. elegans germline
W Gu, M Shirayama, D Conte, J Vasale, PJ Batista… - Molecular cell, 2009 - cell.com
Endogenous small RNAs (endo-siRNAs) interact with Argonaute (AGO) proteins to mediate
sequence-specific regulation of diverse biological processes. Here, we combine deep …
sequence-specific regulation of diverse biological processes. Here, we combine deep …