A fundamental property of many plasma-membrane proteins is their association with the
underlying cytoskeleton to determine cell shape, and to participate in adhesion, motility and …

Meningiomas account for up to 30% of all primary intracranial tumours. They are
histologically classified according to the World Health Organization (WHO) classification of …

Missense mutations of the tumor suppressor Neurofibromin 2 (NF2/Merlin/schwannomin)
result in sporadic to frequent occurrences of tumorigenesis in multiple organs. However, the …

Current models imply that the FERM domain protein Merlin, encoded by the tumor
suppressor NF2, inhibits mitogenic signaling at or near the plasma membrane. Here, we …

The FERM domain protein Merlin, encoded by the NF2 tumor suppressor gene, regulates
cell proliferation in response to adhesive signaling. The growth inhibitory function of Merlin …

The NF2 tumor-suppressor gene was cloned more than a decade ago, but the function of its
encoded protein, Merlin, remains elusive. Merlin, like the closely related ERM proteins …

The tumor suppressor Merlin/NF2 functions upstream of the core Hippo pathway kinases
Lats1/2 and Mst1/2, as well as the nuclear E3 ubiquitin ligase CRL4 DCAF1. Numerous …

The neurofibromatosis type 2 (NF2) gene encodes merlin, a tumor suppressor protein
frequently inactivated in schwannoma, meningioma, and malignant mesothelioma (MM) …

Despite recent studies implicating liquid-like biomolecular condensates in diverse cellular
processes, many biomolecular condensates exist in a solid-like state, and their function and …

Recent studies highlight the importance of the distribution of membrane receptors in
controlling receptor output and in contributing to complex biological processes. The cortical …