Challenges of heterotopic ossification—molecular background and current treatment strategies

P Łęgosz, K Drela, Ł Pulik… - Clinical and …, 2018 - Wiley Online Library
Heterotopic ossification (HO) is an abnormal formation of mature lamellar bone within
extraskeletal soft tissues, such as muscles, tendons, and ligaments. This process is thought …

The effect of type 2 diabetes mellitus and obesity on muscle progenitor cell function

S Teng, P Huang - Stem cell research & therapy, 2019 - Springer
In addition to its primary function to provide movement and maintain posture, the skeletal
muscle plays important roles in energy and glucose metabolism. In healthy humans, skeletal …

Genetic and acquired heterotopic ossification: a translational tale of mice and men

S Cappato, R Gamberale, R Bocciardi, S Brunelli - Biomedicines, 2020 - mdpi.com
Heterotopic ossification is defined as an aberrant formation of bone in extraskeletal soft
tissue, for which both genetic and acquired conditions are known. This pathologic process …

Mechanism of traumatic heterotopic ossification: In search of injury‐induced osteogenic factors

L Li, RS Tuan - Journal of cellular and molecular medicine, 2020 - Wiley Online Library
Heterotopic ossification (HO) is a pathological condition of abnormal bone formation in soft
tissue. Three factors have been proposed as required to induce HO:(a) osteogenic precursor …

[HTML][HTML] Sustained local ionic homeostatic imbalance caused by calcification modulates inflammation to trigger heterotopic ossification

M Bohner, Y Maazouz, MP Ginebra, P Habibovic… - Acta Biomaterialia, 2022 - Elsevier
Heterotopic ossification (HO) is a condition triggered by an injury leading to the formation of
mature lamellar bone in extraskeletal soft tissues. Despite being a frequent complication of …

Inhibition of phosphatidylinositol 3‐kinase α (PI 3Kα) prevents heterotopic ossification

JA Valer, C Sánchez‐de‐Diego, B Gámez… - EMBO Molecular …, 2019 - embopress.org
Heterotopic ossification (HO) is the pathological formation of ectopic endochondral bone
within soft tissues. HO occurs following mechanical trauma, burns, or congenitally in patients …

Regenerative peripheral nerve interfaces for the treatment and prevention of neuromas and neuroma pain

NG Kumar, TA Kung - Hand Clinics, 2021 - hand.theclinics.com
Neuromas are a manifestation of aimless and disorganized neural regeneration that occurs
after transection of a peripheral nerve without repair and can be symptomatic or …

Mkx‐Deficient Mice Exhibit Hedgehog Signaling–Dependent Ectopic Ossification in the Achilles Tendons

H Liu, J Xu, R Jiang - Journal of Bone and Mineral Research, 2019 - academic.oup.com
Heterotopic ossification is the abnormal formation of mineralized bone in skin, muscle,
tendon, or other soft tissues. Tendon ossification often occurs from acute tendon injury or …

Calcified apoptotic vesicles from PROCR+ fibroblasts initiate heterotopic ossification

J Yan, B Gao, C Wang, W Lu, W Qin… - Journal of …, 2024 - Wiley Online Library
Heterotopic ossification (HO) comprises the abnormal formation of ectopic bone in
extraskeletal soft tissue. The factors that initiate HO remain elusive. Herein, we found that …

The survey of cells responsible for heterotopic ossification development in skeletal muscles—human and mouse models

Ł Pulik, B Mierzejewski, MA Ciemerych, E Brzóska… - Cells, 2020 - mdpi.com
Heterotopic ossification (HO) manifests as bone development in the skeletal muscles and
surrounding soft tissues. It can be caused by injury, surgery, or may have a genetic …