Human protozoan diseases represent a serious health problem worldwide, affecting mainly
people in social and economic vulnerability. These diseases have attracted little investment …

In trypanosomatids, polyamine and trypanothione pathways can be considered as a whole
unique metabolism, where most enzymes are essential for parasitic survival and infectivity …

Trypanothione synthetase (TryS) catalyses the synthesis of N 1, N8-bis (glutathionyl)
spermidine (trypanothione), which is the main low molecular mass thiol supporting several …

Severe infections with potentially fatal outcomes are caused by parasites from the genera
Trypanosoma and Leishmania (class Kinetoplastea). The diseases affect people of remote …

Described herein is a continuous‐flow strategy for the palladium‐catalyzed direct C− H
arylation of indole‐3‐acetic acid derivatives with arenediazonium salts. A fully autonomous …

Leishmania and Trypanosoma parasites are responsible for the challenging neglected
tropical diseases leishmaniases, Chagas disease, and human African trypanosomiasis …

Chagas´ disease continues to be a challenging and neglected public health problem in
many American countries. The etiologic agent, Trypanosoma cruzi, develops intracellularly …

Background Chagas cardiomyopathy, caused by Trypanosoma cruzi infection, continues to
be a neglected illness, and has a major impact on global health. The parasite undergoes …

During three decades, only about 20 new drugs have been developed for malaria,
tuberculosis and all neglected tropical diseases (NTDs). This critical situation was reached …

Trypanothione synthetase (TryS) produces N 1, N8-bis (glutathionyl) spermidine (or
trypanothione) at the expense of ATP. Trypanothione is a metabolite unique and essential …