Circular RNA: An emerging frontier in RNA therapeutic targets, RNA therapeutics, and mRNA vaccines

X Liu, Y Zhang, S Zhou, L Dain, L Mei, G Zhu - Journal of Controlled …, 2022 - Elsevier
Circular RNAs (circRNA) is a class of natural (biogenic) or synthetic closed RNA without 5′
or 3′ ends. Meanwhile, their unique covalently-closed structures of circRNA prevent RNA …

The biogenesis, biology and characterization of circular RNAs

LS Kristensen, MS Andersen, LVW Stagsted… - Nature reviews …, 2019 - nature.com
Circular RNAs (circRNAs) are covalently closed, endogenous biomolecules in eukaryotes
with tissue-specific and cell-specific expression patterns, whose biogenesis is regulated by …

Ribosome biogenesis in disease: new players and therapeutic targets

L Jiao, Y Liu, XY Yu, X Pan, Y Zhang, J Tu… - … and Targeted Therapy, 2023 - nature.com
The ribosome is a multi-unit complex that translates mRNA into protein. Ribosome
biogenesis is the process that generates ribosomes and plays an essential role in cell …

[HTML][HTML] Circular RNA-protein interactions: functions, mechanisms, and identification

A Huang, H Zheng, Z Wu, M Chen, Y Huang - Theranostics, 2020 - ncbi.nlm.nih.gov
Circular RNAs (circRNAs) are covalently closed, endogenous RNAs with no 5′ end caps or
3′ poly (A) tails. These RNAs are expressed in tissue-specific, cell-specific, and …

Translation and functional roles of circular RNAs in human cancer

M Lei, G Zheng, Q Ning, J Zheng, D Dong - Molecular cancer, 2020 - Springer
Circular RNAs (circRNAs) are a new class of non-coding RNAs formed by covalently closed
loops through backsplicing. Recent methodologies have enabled in-depth characterization …

[HTML][HTML] Review on circular RNAs and new insights into their roles in cancer

X Tang, H Ren, M Guo, J Qian, Y Yang, C Gu - … and structural biotechnology …, 2021 - Elsevier
Circular RNAs (circRNAs) are a very interesting class of conserved single-stranded RNA
molecules derived from exonic or intronic sequences by precursor mRNA back-splicing …

Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA

P Wu, Y Mo, M Peng, T Tang, Y Zhong, X Deng… - Molecular cancer, 2020 - Springer
Non-coding RNAs do not encode proteins and regulate various oncological processes. They
are also important potential cancer diagnostic and prognostic biomarkers. Bioinformatics …

Circular RNAs: promising biomarkers for human diseases

Z Zhang, T Yang, J Xiao - EBioMedicine, 2018 - thelancet.com
Circular RNA (circRNA) is a group of endogenous noncoding RNA characterized by a
covalently closed cyclic structure lacking poly-adenylated tails. Recent studies have …

[HTML][HTML] Circ-ZNF609 is a circular RNA that can be translated and functions in myogenesis

I Legnini, G Di Timoteo, F Rossi, M Morlando, F Briganti… - Molecular cell, 2017 - cell.com
Circular RNAs (circRNAs) constitute a family of transcripts with unique structures and still
largely unknown functions. Their biogenesis, which proceeds via a back-splicing reaction, is …

[HTML][HTML] Advances in circular RNA and its applications

X Zhao, Y Zhong, X Wang, J Shen… - International Journal of …, 2022 - ncbi.nlm.nih.gov
Circular RNA (circRNA) is a novel endogenous non-coding RNA (ncRNA) that, like
microRNA (miRNA), is a rapidly emerging RNA research topic. CircRNA, unlike traditional …