Coactivator-associated arginine methyltransferase 1 (CARM1) is an arginine
methyltransferase that posttranslationally modifies proteins that regulate multiple levels of …

Arginine methylation is a ubiquitous and relatively stable post-translational modification
(PTM) that occurs in three types: monomethylarginine (MMA), asymmetric dimethylarginine …

Glycine-and arginine-rich (GAR) motifs, commonly found in RNA-binding and-processing
proteins, can be symmetrically (SDMA) or asymmetrically (ADMA) dimethylated at the …

The widespread use of androgen receptor (AR) signaling inhibitors has led to an increased
incidence of AR-negative castration-resistant prostate cancer (CRPC), limiting effective …

Multiple cancers exhibit aberrant protein arginine methylation by both type I arginine
methyltransferases, predominately protein arginine methyltransferase 1 (PRMT1) and to a …

Small cell lung cancer (SCLC) is an epithelial neuroendocrine form of lung cancer for which
survival rates remain dismal and new therapeutic approaches are greatly needed. Key …

CARM1 is predominantly localized in the nucleus and plays a pivotal role in maintaining
mitochondrial homeostasis by regulating gene expression. It suppresses mitochondrial …

Metastasis is a major cause of morbidity and mortality in patients with cancer, highlighting
the need to identify improved treatment and prevention strategies. Previous observations in …

This paper explores the significant role of epigenetics in women's reproductive health,
focusing on the impact of environmental factors. It highlights the crucial link between …

Androgen receptor (AR) splice variants, of which ARv7 is the most common, are increased in
castration-resistant prostate cancer, but the extent to which they drive AR activity is unclear …