Recent advances in pseudouridine detection reveal a complex pseudouridine landscape
that includes messenger RNA and diverse classes of noncoding RNA in human cells. The …

The nucleolus is a distinct subnuclear compartment that was first observed more than 200
years ago. Nucleoli assemble around the tandemly repeated ribosomal DNA gene clusters …

Non-coding RNA (ncRNA) genes produce functional RNA molecules rather than encoding
proteins. However, almost all means of gene identification assume that genes encode …

Small nuclear RNAs (snRNAs) are critical components of the spliceosome that catalyze the
splicing of pre-mRNA. snRNAs are each complexed with many proteins to form RNA-protein …

Summary Pseudouridine (5-ribosyluracil) is a ubiquitous yet enigmatic constituent of
structural RNAs (transfer, ribosomal, small nuclear, and small nucleolar). Although …

Small nucleolar RNAs represent an abundant, evolutionarily ancient group of noncoding
RNAs which possess impressively diverse functions ranging from 2′-O-methylation and …

In eukaryotes, the site-specific formation of the two prevalent types of rRNA modified
nucleotides, 2′-O-methylated nucleotides and pseudouridines, is directed by two large …

Small nucleolar RNAs (snoRNAs) are a large class of small noncoding RNAs present in all
eukaryotes sequenced thus far. As a family, they have been well characterized as playing a …

For a long time it was believed that the nucleotide sequence of every RNA would represent
a simple copy of its coding DNA. This axiom of molecular biology, however, has suffered …

We have identified three C/D-box small nucleolar RNAs (snoRNAs) and one H/ACA-box
snoRNA in mouse and human. In mice, all four snoRNAs (MBII-13, MBII-52, MBII-85, and …