The quest for blood-compatible materials: Recent advances and future technologies

M Hedayati, MJ Neufeld, MM Reynolds… - Materials Science and …, 2019 - Elsevier
The development of blood-compatible materials represents a grand challenge in
biomaterials science. Blood is a complex fluid containing many types of living cells …

Microfluidics to mimic blood flow in health and disease

B Sebastian, PS Dittrich - Annual review of fluid mechanics, 2018 - annualreviews.org
Throughout history, capillary systems have aided the establishment of the fundamental laws
of blood flow and its non-Newtonian properties. The advent of microfluidics technology in the …

Nematic fibrin fibers enabling vascularized thrombus implants facilitate scarless cutaneous wound healing

SH Jung, BH Jang, S Kwon, SJ Park… - Advanced …, 2023 - Wiley Online Library
Autologous implantable scaffolds that induce vasculogenesis have shown great potential in
tissue regeneration; however, previous attempts mainly relied on cell‐laden hydrogel …

Platelet mechanotransduction

CE Hansen, Y Qiu, OJT McCarty… - Annual review of …, 2018 - annualreviews.org
The vasculature is a dynamic environment in which blood platelets constantly survey the
endothelium for sites of vessel damage. The formation of a mechanically coherent …

Biomechanical activation of blood platelets via adhesion to von Willebrand factor studied with mesoscopic simulations

AV Belyaev, YK Kushchenko - Biomechanics and Modeling in …, 2023 - Springer
Platelet adhesion and activation are essential initial processes of arterial and microvascular
hemostasis, where high hydrodynamic forces from the bloodflow impede coagulation. The …

Arterial thrombus stability: does it matter and can we detect it?

DA Gorog, ZA Fayad, V Fuster - Journal of the American College of …, 2017 - jacc.org
The spontaneous lysis of a coronary thrombus is a natural protective mechanism against
lasting occlusion and downstream infarction. Thrombus stability is thus a direct determinant …

Mathematical and computational modeling of device-induced thrombosis

KB Manning, F Nicoud, SM Shea - Current opinion in biomedical …, 2021 - Elsevier
Given the extensive and routine use of cardiovascular devices, a major limiting factor to their
success is the thrombotic rate that occurs. This poses direct risk to the patient and requires …

Quantitative image analysis of thrombus formation in microfluidic in-vitro models

JS Choi, DH Ham, JH Kim, HBF Marcial… - Micro and Nano …, 2022 - Springer
In this study, we present a method to quantitatively analyze the thrombus formation process
through image analysis in an in vitro thrombus model with a circular cross section. The …

[HTML][HTML] Why platelet mechanotransduction matters for hemostasis and thrombosis

O Oshinowo, SS Azer, J Lin, WA Lam - Journal of Thrombosis and …, 2023 - Elsevier
Mechanotransduction is the ability of cells to “feel” or sense their mechanical
microenvironment and integrate and convert these physical stimuli into adaptive …

Toward modeling thrombosis and thromboembolism in laminar and turbulent flow regimes

N Tobin, KB Manning - International journal for numerical …, 2022 - Wiley Online Library
Thrombosis and thromboembolism are deadly risk factors in blood‐contacting biomedical
devices, and in‐silico models of thrombosis are attractive tools to understand the mechanics …