Fluorescence nanoscopy uniquely combines minimally invasive optical access to the
internal nanoscale structure and dynamics of cells and tissues with molecular detection …

Protein misfolding and aggregation, a key contributor to the progression of numerous
neurodegenerative diseases, results in functional deficiencies and the creation of harmful …

Far-field optical microscopy using focused light is an important tool in a number of scientific
disciplines including chemical,(bio) physical and biomedical research, particularly with …

Despite its short history, diffraction-unlimited fluorescence microscopy techniques have
already made a substantial imprint in the biological sciences. In this review, we describe …

Fluorescence imaging techniques play a pivotal role in our understanding of the nervous
system. The emergence of various super-resolution microscopy methods and specialized …

Several hereditary neurological and neuromuscular diseases are caused by an abnormal
expansion of trinucleotide repeats. To date, there have been 10 of these trinucleotide repeat …

Neural stem and progenitor cells (NSPCs) are critical for continued cellular replacement in
the adult brain. Lifelong maintenance of a functional NSPC pool necessitates stringent …

Polyglutamine expansion in the huntingtin protein is the primary genetic cause of
Huntington's disease (HD). Fragments coinciding with mutant huntingtin exon1 aggregate in …

The presumptive altered dynamics of transient molecular interactions in vivo contributing to
neurodegenerative diseases have remained elusive. Here, using single-molecule …

Polyglutamine (polyQ) diseases are a group of neurodegenerative disorders, involving the
deposition of aggregation-prone proteins with long polyQ expansions. However, the …