One of the features of primate immunodeficiency viruses (HIVs and SIVs) that distinguishes
them from other retroviruses is the array of" accessory" proteins they encode. Here, we …

Infectious diseases are one of the main causes of human morbidity and mortality. In the last
few decades, pathogenic microorganisms' resistance to conventional drugs has been …

Human immunodeficiency virus type 1 (HIV-1) utilizes Vpu, Env, and Nef to down-modulate
its primary CD4 receptor from the cell surface, and this function seems to be critical for the …

Nef is a multifunctional accessory protein of primate lentiviruses. Recently, it has been
shown that the ability of Nef to downmodulate CD4, CD28, and class I major …

Abstract The HIV and SIV Nef accessory proteins are potent enhancers of viral persistence
and accelerate progression to AIDS in HIV-1-infected patients and non-human primate …

Background Nef is an accessory protein of primate lentiviruses, HIV-1, HIV-2 and SIV.
Besides removing CD4 and MHC class I from the surface and activating cellular signaling …

Lentiviral Nefs recruit assembly polypeptide complexes and target sorting motifs in cellular
receptors to induce their internalization. While Nef-mediated CD4 downmodulation is …

The Nef protein is an essential factor for lentiviral pathogenesis in humans and other
simians. Despite a multitude of functions attributed to this protein, the exact role of Nef in …

The covalent conjugation of a 14-carbon saturated fatty acid (myristic acid) to the amino-
terminal glycine residue is critical for some viral proteins to function. This protein lipidation …

Interaction of the human immunodeficiency virus type 1 (HIV-1) Nef protein with p21-
activated kinase 2 (PAK2) has been proposed to play a role in T-cell activation, viral …