As the crucial non-cellular component of tissues, the extracellular matrix (ECM) provides
both physical support and signaling regulation to cells. Some ECM molecules provide a …

In epithelial cancers, cells must invade through basement membranes (BMs) to metastasize.
The BM, a thin layer of extracellular matrix underlying epithelial and endothelial tissues, is …

Breast cancer becomes invasive when carcinoma cells invade through the basement
membrane (BM)—a nanoporous layer of matrix that physically separates the primary tumour …

When crawling through the body, leukocytes often traverse tissues that are densely packed
with extracellular matrix and other cells, and this raises the question: How do leukocytes …

The basement membrane (BM) is a special type of extracellular matrix that lines the basal
side of epithelial and endothelial tissues. Functionally, the BM is important for providing …

Matrix metalloproteinases (MMPs) are associated with decreased patient prognosis but
have failed as anti-invasive drug targets despite promoting cancer cell invasion. Through …

Unraveling the mechanisms that govern the formation and function of invadopodia is
essential towards the prevention of cancer spread. Here, we characterize the ultrastructural …

This review describes how direct visualization of the dynamic interactions of cells with
different extracellular matrix microenvironments can provide novel insights into complex …

Macrophages and cancer cells populations are posited to navigate basement membrane
barriers by either mobilizing proteolytic enzymes or deploying mechanical forces …

Background Lung adenocarcinoma (LUAD) remains a global health concern with its poor
prognosis and high mortality. Whether tumor cells invade through the basement membrane …