Advanced glycation end products (AGEs) are formed as a result of non-enzymatic reaction
between the free reducing sugars and proteins, lipids, or nucleic acids. AGEs are …

Immunosenescence is characterized by a decreased ability of the immune system to
respond to foreign antigens, as well as a decreased ability to maintain tolerance to self …

Immunosenescence involves age-related remodeling changes in the organization of
lymphoid organs and functionality of immune cells, which have been associated with …

According to the oxidation-inflammation theory of aging, chronic oxidative stress and
inflammatory stress situations (with higher levels of oxidant and inflammatory compounds …

Age‐associated deterioration in the immune system, which is referred to as
immunosenescence, contributes to an increased susceptibility to infectious diseases …

Background Chronic inflammation brought on by oxidative stress can result in several
immunopathologies. Natural compounds with antioxidant characteristics, like quercetin …

A hallmark of aging is an imbalance between production and clearance of reactive oxygen
species and increased levels of oxidatively damaged biomolecules. Herein, we demonstrate …

Objective: The aim of this study was to evaluate a possible synergism between AGE-RAGE
and TLR4 signaling and the role of p38 MAPK and NF-kB signaling pathways on the …

Statins inhibiting 3-hydroxy-3-methylglutaryl-CoA reductase are the standard treatment for
hypercholesterolemia in atherosclerotic cardiovascular disease (ASCVD), mediated by …

Chronic hyperglycemia, which is present in all types of diabetes, increases the formation of
advanced glycation end-products (AGEs). The interaction of AGEs with receptor of advanced …