Chemistry of the retinoid (visual) cycle
As succinctly summarized by Wolf, 1 lack of vitamin A (all-trans-retinol) was recognized by
ancient Egyptians as causing a visual deficiency involving the retina and cornea that could …
ancient Egyptians as causing a visual deficiency involving the retina and cornea that could …
[HTML][HTML] Retinal pigment epithelium 65 kDa protein (RPE65): An update
PD Kiser - Progress in retinal and eye research, 2022 - Elsevier
Vertebrate vision critically depends on an 11-cis-retinoid renewal system known as the
visual cycle. At the heart of this metabolic pathway is an enzyme known as retinal pigment …
visual cycle. At the heart of this metabolic pathway is an enzyme known as retinal pigment …
Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins
Methods to deliver gene editing agents in vivo as ribonucleoproteins could offer safety
advantages over nucleic acid delivery approaches. We report the development and …
advantages over nucleic acid delivery approaches. We report the development and …
Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo
Prime editing enables precise installation of genomic substitutions, insertions and deletions
in living systems. Efficient in vitro and in vivo delivery of prime editing components, however …
in living systems. Efficient in vitro and in vivo delivery of prime editing components, however …
Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing
Cytosine base editors and adenine base editors (ABEs) can correct point mutations
predictably and independent of Cas9-induced double-stranded DNA breaks (which causes …
predictably and independent of Cas9-induced double-stranded DNA breaks (which causes …
Rapid RGR-dependent visual pigment recycling is mediated by the RPE and specialized Müller glia
In daylight, demand for visual chromophore (11-cis-retinal) exceeds supply by the classical
visual cycle. This shortfall is compensated, in part, by the retinal G-protein-coupled receptor …
visual cycle. This shortfall is compensated, in part, by the retinal G-protein-coupled receptor …
Safer and efficient base editing and prime editing via ribonucleoproteins delivered through optimized lipid-nanoparticle formulations
R Hołubowicz, SW Du, J Felgner, R Smidak… - Nature Biomedical …, 2024 - nature.com
Delivering ribonucleoproteins (RNPs) for in vivo genome editing is safer than using viruses
encoding for Cas9 and its respective guide RNA. However, transient RNP activity does not …
encoding for Cas9 and its respective guide RNA. However, transient RNP activity does not …
Key enzymes of the retinoid (visual) cycle in vertebrate retina
A major goal in vision research over the past few decades has been to understand the
molecular details of retinoid processing within the retinoid (visual) cycle. This includes the …
molecular details of retinoid processing within the retinoid (visual) cycle. This includes the …
Structural basis of carotenoid cleavage: from bacteria to mammals
Carotenoids and their metabolic derivatives serve critical functions in both prokaryotic and
eukaryotic cells, including pigmentation, photoprotection and photosynthesis as well as cell …
eukaryotic cells, including pigmentation, photoprotection and photosynthesis as well as cell …
The carotenoid cleavage dioxygenase CCD 2 catalysing the synthesis of crocetin in spring crocuses and saffron is a plastidial enzyme
O Ahrazem, A Rubio‐Moraga, J Berman… - New …, 2016 - Wiley Online Library
The apocarotenoid crocetin and its glycosylated derivatives, crocins, confer the red colour to
saffron. Crocetin biosynthesis in saffron is catalysed by the carotenoid cleavage …
saffron. Crocetin biosynthesis in saffron is catalysed by the carotenoid cleavage …