Somatic mosaicism, the occurrence of multiple genetically distinct cell clones within the
same tissue, is an evitable consequence of human aging. The hematopoietic system is no …

Major causes of morbidity and mortality in myeloproliferative neoplasms are represented by
arterial and venous complications, progression to myelofibrosis, and transformation to acute …

Accurate prediction of thrombosis in essential thrombocythemia (ET) provides the platform
for prospective studies exploring preventive measures. Current risk stratification for …

Diagnosis of essential thrombocythemia (ET) has been updated in the last World Health
Organization (WHO) classification. We developed a prognostic model to predict survival at …

1Guy's and St Thomas' NHS Foundation Trust, London, 2Russells Hall Hospital, Dudley,
West Midlands, 3Arrowe Park Hospital Arrowe Park Road Upton Wirral, 4Wellcome Trust …

Ischemic stroke has a high recurrence rate despite treatment. This underlines the
significance of investigating new possible cerebrovascular risk factors, such as the acquired …

We assessed frequency and predictive factors for major cardiovascular (CV) events in 707
patients with primary myelofibrosis (PMF) followed in 4 European institutions. A total of 236 …

The effectiveness of antiplatelet therapy as primary prophylaxis for thrombosis in low-risk
essential thrombocythemia (ET) is not proven. In this study, the incidence rates of arterial …

Thrombosis is a leading cause of morbidity and mortality in patients with Philadelphia
chromosome–negative myeloproliferative neoplasms (MPNs), particularly polycythemia vera …

JAK2-V617F–positive chronic myeloproliferative neoplasia (CMN) commonly displays
dysfunction of integrins and adhesion molecules expressed on platelets, erythrocytes, and …