Persistent DNA double-strand breaks (DSBs) in neurons are an early pathological hallmark
of neurodegenerative diseases including Alzheimer's disease (AD), with the potential to …

Li-Fraumeni syndrome is a rare yet serious hereditary cancer predisposition syndrome,
marked by a significant early-life increased risk of developing cancer. Primarily caused by …

Inadequate remnant volume and regenerative ability of the liver pose life-threatening risks to
patients after partial liver transplantation (PLT) or partial hepatectomy (PHx), while few …

During aging, skin homeostasis is essential for maintaining appearance, as well as
biological defense of the human body. In this study, we identified thrombospondin-1 …

Cellular senescence is a hallmark of ageing and it plays a key role in the development of
age-related diseases. Abdominal aortic aneurysm (AAA) is an age related degenerative …

Human adenoviruses (HAdV) are classified as DNA tumor viruses due to their potential to
mediate oncogenic transformation in non-permissive mammalian cells and certain human …

Aging is a natural and inevitable process of organisms. With the intensification of population
aging, research on aging has become a hot topic of global attention. The most obvious …

Cell lines derived from fish tissues are resistant to premature senescence under typical
culture conditions. Previously, we demonstrated that fish genomes do not have a p16 …

Down syndrome (DS), the most common genetic cause of intellectual disability, is
associated with lifelong cognitive deficits. However, the mechanisms by which triplication of …

In response to chemotherapy and radiotherapy, a subset of resistant cancer cells avoids cell
death by entering a stable state known as senescence, characterized by prolonged cell …