Adoptive cell therapy (ACT) with tumor-specific T cells has been shown to mediate durable
cancer regression. Tumor-specific T cells are also the basis of other therapies, notably …

Neoantigen immunogenicity prediction is a burgeoning field with vast potential; however, the
shortage of high-quality data and biases in current datasets limit model generalizability …

Nanopore direct RNA sequencing (DRS) has emerged as a powerful tool for RNA
modification identification. However, concurrently detecting multiple types of modifications in …

Raman spectroscopy has become an important single-cell analysis tool for monitoring
biochemical changes at the cellular level. However, Raman spectral data, typically …

Peptide binding to major histocompatibility complex (MHC) proteins plays a critical role in T-
cell recognition and the specificity of the immune response. Experimental validation such …

While significant strides have been made in predicting neoepitopes that trigger autologous
CD4+ T cell responses, accurately identifying the antigen presentation by human leukocyte …

Cancer immunotherapy represents a paradigm shift in oncology, offering a superior anti-
tumor efficacy and the potential for durable remission. The success of personalized vaccines …

Neoantigen immunogenicity prediction is a highly challenging problem in the development
of personalised medicines. Low reactivity rates in called neoantigens result in a difficult …

Neoantigens, formed by genetic mutations in tumor cells, are abnormal peptides that can
trigger immune responses. Precisely identifying neoantigens from vast mutations is the key …

CD8+ T-cell activation is initiated by the recognition of epitopes presented on class I major
histocompatibility complex (MHC-I) molecules. Identifying such epitopes is useful for …