Angiogenesis involves a series of tightly regulated cellular processes initiated primarily by
the vascular endothelial growth factor (VEGF). The urokinase-type plasminogen activator …

Cellular senescence, an integral component of aging and cancer, arises in response to
diverse triggers, including telomere attrition, macromolecular damage and signaling from …

Alternatively activated “M2” macrophages are believed to function during late stages of
wound healing, behaving in an anti-inflammatory manner to mediate the resolution of the …

Currently, there are about 20 antiepileptic drugs on market. Still, seizures in about 30% of
patients with epilepsy are not adequately controlled, or the drugs cause quality-of-life …

Reactive oxygen species, ROS, are regulators of endothelial cell migration, proliferation and
survival, events critically involved in angiogenesis. Different isoforms of ROS-generating …

Rationale: Patients with colorectal cancer die mainly due to liver metastases (CRC-LM).
Although the tumor microenvironment (TME) plays an important role in tumor development …

Background Clinical decision making in abdominal aortic aneurysms (AAA) relies
completely on diameter. At this point, improved decision tools remain an unmet medical …

Gene silencing by DNA hypermethylation of CpG islands is a well‐characterized
phenomenon in cancer. The effect of hypomethylation in particular of non‐CpG island genes …

Follicle development is characterized by the recruitment, growth, selection, and dominance
of follicles, and follicle selection determines the lifetime reproductive performance. However …

We previously reported a genetic analysis of heart failure traits in a population of inbred
mouse strains treated with isoproterenol to mimic catecholamine-driven cardiac hypertrophy …